Functional genomics: from genes to new therapies

被引：20

作者：

Dyer, MR ^{[1
]}

Cohen, D

Herrling, PL

机构：

[1] Novartis Pharma, CH-4002 Basel, Switzerland

[2] Novartis Pharmaceut, Summit, NJ 07901 USA

来源：

DRUG DISCOVERY TODAY | 1999年 / 4卷 / 03期

关键词：

D O I：

10.1016/S1359-6446(99)01310-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The application of genomics in pharmaceutical R&D is presently one of the central issues in the industry. The evolution of functional genomics approaches and their integration into a technology platform for therapeutic discovery is a challenging and complex process, In this review, the authors describe how functional genomics will offer significant opportunities in the search for causal and disease-modifying therapies for better treatment of society's most outstanding medical needs.

引用

页码：109 / 114

页数：6

共 22 条

[1]

COHEN GD, 1993, SEQUENCES, V2, P36

[2] HOW MANY GENES IN THE HUMAN GENOME [J].

FIELDS, C ;

ADAMS, MD ;

WHITE, O ;

VENTER, JC .

NATURE GENETICS, 1994, 7 (03) :345-346

[3]

Goedert M, 1997, NATURE, V388, P232, DOI 10.1038/40767

[4]

Herrling PL, 1998, NATURE, V392, P32

[5]

Kahn CR, 1996, ANNU REV MED, V47, P509

[6]

Kingsbury DT, 1997, DRUG DEVELOP RES, V41, P120, DOI 10.1002/(SICI)1098-2299(199707/08)41:3/4<120::AID-DDR3>3.0.CO

[7]

2-N

[8] DIFFERENTIAL DISPLAY OF EUKARYOTIC MESSENGER-RNA BY MEANS OF THE POLYMERASE CHAIN-REACTION [J].

LIANG, P ;

PARDEE, AB .

SCIENCE, 1992, 257 (5072) :967-971

[9]

Lillie J, 1997, DRUG DEVELOP RES, V41, P160, DOI 10.1002/(SICI)1098-2299(199707/08)41:3/4<160::AID-DDR6>3.0.CO

[10]

2-J

← 1 2 3 →