Role of the MMP9 Gene in Hemorrhagic Transformations After Tissue-Type Plasminogen Activator Treatment in Stroke Patients

被引：17

作者：

Fernandez-Cadenas, Israel ^{[1
,2
]}

del Rio-Espinola, Alberto ^{[1
,2
]}

Carrera, Caty ^{[1
,2
]}

Domingues-Montanari, Sophie ^{[1
,2
]}

Mendioroz, Maite ^{[1
,2
]}

Delgado, Pilar ^{[1
,2
]}

Rosell, Anna ^{[1
,2
]}

Ribo, Marc ^{[1
,2
]}

Giralt, Dolors ^{[1
,2
]}

Quintana, Manolo ^{[1
,2
]}

Castellanos, Mar ^{[3
]}

Obach, Victor ^{[4
]}

Martinez, Sergi ^{[5
]}

Mar Freijo, Mari ^{[6
]}

Jimenez-Conde, Jordi ^{[7
]}

Roquer, Jaume ^{[7
]}

Marti-Fabregas, Joan ^{[5
]}

Molina, Carlos A. ^{[1
,2
]}

Alvarez-Sabin, Jose ^{[1
,2
]}

Montaner, Joan ^{[1
,2
]}

机构：

[1] UAB, Neurovasc Res Lab, Dept Med, Inst Recerca Vall dHebron,Vall dHebron Hosp, Barcelona 08035, Spain

[2] UAB, Neurol Unit, Dept Med, Vall dHebron Res Inst,Vall dHebron Hosp, Barcelona 08035, Spain

[3] Hosp Univ Dr Josep Trueta, Inst Invest Biomed Girona, Dept Neurol, Girona, Spain

[4] Univ Barcelona, Dept Neurol Sci, Hosp Clin, E-08007 Barcelona, Spain

[5] Hosp Santa Creu & Sant Pau, Dept Neurol, Barcelona, Spain

[6] Hosp Basurto, Dept Neurol, Bilbao, Spain

[7] Hosp Mar, Dept Neurol, Barcelona, Spain

来源：

STROKE | 2012年 / 43卷 / 05期

关键词：

genetics; tissue-type plasminogen activator; THROMBOLYSIS; POLYMORPHISM; ALTEPLASE; THERAPY;

D O I：

10.1161/STROKEAHA.111.639823

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-Despite the benefits of tissue-type plasminogen activator treatment, some stroke patients experience adverse hemorrhagic transformations (HT). Plasma protein levels of MMP9 have been associated with HT occurrence. We aimed to analyze the association of the MMP9 gene with HT occurrence. Methods-We analyzed the MMP9 gene in blood samples from 885 stroke patients treated with tissue-type plasminogen activator by tag-SNP, imputed SNP, direct sequencing, and RNA expression. Results-We did not observe any significant association between MMP9 genetic variations or MMP9 expression and HT occurrence. Moreover, no association was found between MMP9 expression and MMP9 polymorphisms. Conclusions-Genetic variations in the MMP9 gene are not associated with HT occurrence in tissue-type plasminogen activator-treated patients. (Stroke. 2012;43:1398-1400.)

引用

页码：1398 / +

页数：13

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