Neurexin 1α structural variants associated with autism

被引：117

作者：

Yan, Jin ^{[1
]}

Noltner, Katie ^{[1
]}

Feng, Jinong ^{[1
]}

Li, Wenyan ^{[1
]}

Schroer, Richard ^{[3
]}

Skinner, Cindy ^{[3
]}

Zeng, Wenqi ^{[2
]}

Schwartz, Charles E. ^{[3
]}

Sommer, Steve S. ^{[1
,2
]}

机构：

[1] City Hope Natl Med Ctr, Dept Mol Genet, Duarte, CA 91010 USA

[2] City Hope Natl Med Ctr, Dept Mol Diag, Duarte, CA 91010 USA

[3] Greenwood Genet Ctr, Greenwood, SC 29646 USA

来源：

NEUROSCIENCE LETTERS | 2008年 / 438卷 / 03期

关键词：

autism; alpha-neurexin genes; mutation detection;

D O I：

10.1016/j.neulet.2008.04.074

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurexins are presynaptic membrane cell-adhesion molecules which bind to neuroligins, a family of proteins that are associated with autism. To explore the possibility that structural variants in the neurexin alpha genes predispose to autism, the coding regions and associated splice junctions of the neurexin 1 alpha gene were sequenced in 116 Caucasian patients with autism and 192 Caucasian controls. Five ultra-rare structural variants including a predicted splicing mutation were found in patients with autism and absent in 10,000 control alleles. Only one ultra-rare structural variant was found in controls (5/116 vs. 1/192; P= 0.03, Fisher's exact test, one-sided). In the context of all available data, the ultra-rare structural variants of the neurexin 1 alpha gene are consistent with mutations predisposing to autism. (c) 2008 Elsevier Ireland Ltd. All rights reserved

引用

页码：368 / 370

页数：3

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