Serum antibodies to periodontal pathogens and markers of systemic inflammation

被引:84
作者
Dye, BA
Choudhary, K
Shea, S
Papapanou, PN
机构
[1] Columbia Univ, Sch Dent & Oral Surg, Sect Oral & Diagnost Sci, Div Periodont, New York, NY 10032 USA
[2] Natl Ctr Hlth Stat, Ctr Dis Control & Prevent, Huntsville, MD USA
[3] Columbia Univ, Dept Med, New York, NY USA
[4] Columbia Univ, Dept Epidemiol, New York, NY USA
关键词
Actinobacillus actinomycetemcomitans; antibody; C-reactive protein; fibrinogen; IgG; NHANES III; periodontitis; Porphyromonas gingivalis;
D O I
10.1111/j.1600-051X.2005.00856.x
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
We examined the relationship between serum antibodies against Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans, and plasma fibrinogen and serum C-reactive protein (CRP) in a nationally representative sample. Data on 2973 participants aged 40 years and older from the third National Health and Nutrition Examination Survey, second phase (1991-1994) were used. Three logistic regression models adjusted for gender, race, educational attainment, diabetes, cigarette smoking, body mass index (BMI), and other inflammatory conditions were constructed, based on three different assumptions: (A) no access to dental/periodontal data; (B) knowledge of number of teeth present but not of clinical periodontal status; and (C) knowledge of both dental and clinical periodontal status. High fibrinogen (> 400 mg/dl) was unrelated to P. gingivalis and A. actinomycetemcomitans antibodies in all models. High CRP (> 0.4 mg/dl) was related to high antibody levels to P. gingivalis in models A [odds ratios (OR) 1.63, 95% confidence intervals (CI) 1.15-2.32], B (OR 1.69, 95% CI 1.18-2.41), and C (OR 1.58, 95% CI 1.12-2.23). In model C, high CRP was related to > 30% extent of attachment loss of >= 3 mm (OR 1.58, 95% CI 1.19-2.08). Antibodies to A. actinomycetemcomitans were not associated with high CRP levels in any model. High serum titre to P. gingivalis and the presence of periodontal disease are independently related to high CRP levels.
引用
收藏
页码:1189 / 1199
页数:11
相关论文
共 68 条
[1]   Environmental tobacco smoke and periodontal disease in the United States [J].
Arbes, SJ ;
Agustsdóttir, H ;
Slade, GD .
AMERICAN JOURNAL OF PUBLIC HEALTH, 2001, 91 (02) :253-257
[2]   Obesity is the major determinant of elevated C-reactive protein in subjects with the metabolic syndrome [J].
Aronson, D ;
Bartha, P ;
Zinder, O ;
Kerner, A ;
Markiewicz, W ;
Avizohar, O ;
Brook, GJ ;
Levy, Y .
INTERNATIONAL JOURNAL OF OBESITY, 2004, 28 (05) :674-679
[3]   Periodontal disease and cardiovascular disease [J].
Beck, J ;
Garcia, R ;
Heiss, G ;
Vokonas, PS ;
Offenbacher, S .
JOURNAL OF PERIODONTOLOGY, 1996, 67 (10) :1123-1137
[4]   Relationship of periodontal disease to carotid artery intima-media wall thickness - The atherosclerosis risk in communities (ARIC) study [J].
Beck, JD ;
Elter, JR ;
Heiss, G ;
Couper, D ;
Mauriello, SM ;
Offenbacher, S .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2001, 21 (11) :1816-1822
[5]  
BECK JD, 2005, IN PRESS ANN PERIODO, V10
[6]   Need to test the arterial inflammation hypothesis [J].
Bhatt, DL ;
Topol, EJ .
CIRCULATION, 2002, 106 (01) :136-140
[7]   CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease - Application to Clinical and Public Health Practice - Clinical use of inflammatory markers in patients with cardiovascular diseases - A background paper [J].
Biasucci, LM .
CIRCULATION, 2004, 110 (25) :E560-E567
[8]   Relation of markers of inflammation (C-reactive protein, fibrinogen, von Willebrand factor, and leukocyte count) and statin therapy to long-term mortality in patients with angiographically proven coronary artery disease [J].
Bickel, C ;
Rupprecht, HJ ;
Blankenberg, S ;
Espiniola-Klein, C ;
Schlitt, A ;
Rippin, G ;
Hafner, G ;
Treude, R ;
Othman, H ;
Hofmann, KP ;
Meyer, J .
AMERICAN JOURNAL OF CARDIOLOGY, 2002, 89 (08) :901-908
[9]   Comparison of differing C-reactive protein assay methods and their impact on cardiovascular risk assessment [J].
Clarke, JL ;
Anderson, JL ;
Carlquist, JF ;
Roberts, RF ;
Horne, BD ;
Bair, TL ;
Kolek, MJ ;
Mower, CP ;
Crane, AM ;
Roberts, WL ;
Muhlestein, JB .
AMERICAN JOURNAL OF CARDIOLOGY, 2005, 95 (01) :155-158
[10]   Relationship of destructive periodontal disease to the acute-phase response [J].
Craig, RG ;
Yip, JK ;
So, MK ;
Boylan, RJ ;
Socransky, SS ;
Haffajee, AD .
JOURNAL OF PERIODONTOLOGY, 2003, 74 (07) :1007-1016