Angiogenic gene therapy for heart disease: a review of animal studies and clinical trials

被引：37

作者：

Hammond, HK

McKirnan, MD

机构：

[1] Univ Calif San Diego, Dept Med, San Diego VA Healthcare Syst, San Diego, CA 92161 USA

[2] Collateral Therapeut, San Diego, CA USA

来源：

CARDIOVASCULAR RESEARCH | 2001年 / 49卷 / 03期

关键词：

D O I：

10.1016/S0008-6363(00)00257-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The current published clinical literature on angiogenic gene therapy for the treatment of myocardial ischemia does not include a single randomized, placebo-controlled trial. Based on current clinical literature, it is an unproven therapy. Successful animal studies combined with published reports of good outcomes in patients enrolled in uncontrolled trials has led to the expectation that angiogenic gene therapy will ultimately become a clinical reality. The next important landmark in the field will be the publication of data showing a favorable effect of angiogenic gene transfer in placebo-controlled, blinded clinical trials. (C) 2001 Elsevier Science B.V. All rights reserved.

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页码：561 / 567

页数：7

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