The Genetics of Child Psychiatric Disorders: Focus on Autism and Tourette Syndrome

被引：110

作者：

State, Matthew W. ^{[1
,2
,3
]}

机构：

[1] Yale Univ, Sch Med, Dept Child Psychiat, New Haven, CT 06510 USA

[2] Yale Univ, Sch Med, Dept Psychiat & Genet, New Haven, CT 06510 USA

[3] Yale Univ, Sch Med, Program Neurogenet, New Haven, CT 06510 USA

来源：

NEURON | 2010年 / 68卷 / 02期

关键词：

FRAGILE-X-SYNDROME; SCAFFOLDING PROTEIN SHANK3; GENOME-WIDE ASSOCIATION; COPY NUMBER VARIATION; SPECTRUM-DISORDER; RARE VARIANTS; RECEPTOR GENE; RECURRENT REARRANGEMENTS; BILINEAL TRANSMISSION; MENTAL-RETARDATION;

D O I：

10.1016/j.neuron.2010.10.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Investigations into the genetics of child psychiatric disorders have finally begun to shed light on molecular and cellular mechanisms of psychopathology. The first strains of success in this notoriously difficult area of inquiry are the result of an increasingly sophisticated appreciation of the allelic architecture of common neuropsychiatric and neurodevelopmental disorders, the consolidation of large patient cohorts now beginning to reach sufficient size to power reliable studies, the emergence of genomic tools enabling comprehensive investigations of rare as well as common genetic variation, and advances in developmental neuroscience that are fueling the rapid translation of genetic findings.

引用

页码：254 / 269

页数：16

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