Independent origin of functional MHC class II genes in humans and New World monkeys

被引:24
作者
Kriener, K [1 ]
O'hUigin, C [1 ]
Klein, J [1 ]
机构
[1] Max Planck Inst Biol, Immungenet Abt, D-72076 Tubingen, Germany
关键词
major histocompatibility complex; platyrrhini; DRB; DQA; DQB; DPB;
D O I
10.1016/S0198-8859(00)00233-0
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In previous studies, major histocompatibility complex (MHC) class II DP, DQ, and DR families of genes were characterized in different primate species mostly on the basis of their second exon sequences. Resemblances were found between Old World monkey (OWM) and New World monkey (NWM) genes and were interpreted as being the result of transspecies evolution. Subsequent analysis of intron sequences of catarrhine and platyrrhine DRB genes, however, revealed that the amplifiable gents were not, in fact, orthologous. To test other DRB genes and other families of the class II region Southern blot hybridizations were carried out with tamarin genomic DNA using probes specific for the third exons of the tamarin DQA, DQB, DPB, and DRB genes. The hybridizing bands were extracted from the gel and the third exons of the genes were amplified by PCR, cloned, and sequenced. With two exceptions, all NWM class II genes were found to group separately from the human sequences. Only the sequences of one nonfunctional DQB locus appeared to be more closely related to human genes than to other platyrrhine DQB genes. In the DRB family one gene was found that grouped with sheep and strepsirhine DRB sequences and might represent an old gene lineage. To extend the sequences to the second exon, long PCRs were performed on tamarin genomic DNA. This approach was successful for five of the ten third exon sequences. From these data, are conclude that at least the functional MHC class II genes have expanded independently in catarrhines and platyrrhines. Human Immunology, 62, 1-14 (2001). (C) American Society for Histocompatibility and Immunogenetics, 2001. Published by Elsevier Science Inc.
引用
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页码:1 / 14
页数:14
相关论文
共 59 条
[1]   The common marmoset:: A new world primate species with limited Mhc class II variability [J].
Antunes, SG ;
de Groot, NG ;
Brok, H ;
Doxiadis, G ;
Menezes, AAL ;
Otting, N ;
Bontrop, RE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (20) :11745-11750
[2]   MARROW CHIMERISM IN MARMOSETS [J].
BENIRSCHKE, K ;
ANDERSON, JM ;
BROWNHILL, LE .
SCIENCE, 1962, 138 (3539) :513-&
[3]   Phylogenetic history of hominoid DRB loci and alleles inferred from intron sequences [J].
Bergström, TF ;
Erlandsson, R ;
Engkvist, H ;
Josefsson, A ;
Erlich, HA ;
Gyllensten, U .
IMMUNOLOGICAL REVIEWS, 1999, 167 :351-365
[4]   DRB, DQA, DQB AND DPB NUCLEOTIDE-SEQUENCES OF SAGUINUS-OEDIPUS B95-8 [J].
BIDWELL, JL ;
LU, P ;
WANG, Y ;
ZHOU, K ;
CLAY, TM ;
BONTROP, RE .
EUROPEAN JOURNAL OF IMMUNOGENETICS, 1994, 21 (01) :67-77
[5]  
BONTROP RE, 1994, IMMUNOGENETICS, V39, P81
[6]   Major histocompatibility complex class II polymorphisms in primates [J].
Bontrop, RE ;
Otting, N ;
de Groot, NG ;
Doxiadis, GGM .
IMMUNOLOGICAL REVIEWS, 1999, 167 :339-350
[7]   Evolution of a new nonclassical MHC class I locus in two Old World primate species [J].
Boyson, JE ;
Iwanaga, KK ;
Urvater, JA ;
Hughes, AL ;
Golos, TG ;
Watkins, DI .
IMMUNOGENETICS, 1999, 49 (02) :86-98
[8]   TRANSSPECIES EVOLUTION OF MHC-DRB HAPLOTYPE POLYMORPHISM IN PRIMATES - ORGANIZATION OF DRB GENES IN THE CHIMPANZEE [J].
BRANDLE, U ;
ONO, H ;
VINCEK, V ;
KLEIN, D ;
GOLUBIC, M ;
GRAHOVAC, B ;
KLEIN, J .
IMMUNOGENETICS, 1992, 36 (01) :39-48
[9]  
CHEN ZW, 1992, J IMMUNOL, V148, P2547
[10]   ALLELIC DIVERSITY AT THE PRIMATE MAJOR HISTOCOMPATIBILITY COMPLEX DRB6 LOCUS [J].
CORELL, A ;
MORALES, P ;
VARELA, P ;
PAZARTAL, E ;
MARTINVILLA, JM ;
MARTINEZLASO, J ;
ARNAIZVILLENA, A .
IMMUNOGENETICS, 1992, 36 (01) :33-38