Pathogenesis of Campylobacter

被引：66

作者：

Poly, Frederic ^{[1
]}

Guerry, Patricia ^{[1
]}

机构：

[1] Naval Med Res Ctr, Enter Dis Dept, Silver Spring, MD 20910 USA

来源：

CURRENT OPINION IN GASTROENTEROLOGY | 2008年 / 24卷 / 01期

关键词：

Campylobacter; flagella; genomics;

D O I：

10.1097/MOG.0b013e3282f1dcb1

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Purpose of review Molecular pathogenesis of Campylobacter jejuni has lagged behind that of other enteric pathogens. This review summarizes advances in the biology and pathogenesis of C. jejuni. Recent findings Multiple genome sequences have defined conserved and hypervariable loci in the C. jejuni genome. Interaction of C. jejuni with eukaryotic cells results in numerous signal transduction changes and release of proinflammatory cytokines. In-vivo models based on immune knockout mice have also revealed new information on pathogenesis. Summary New information and new methods are available that should provide important tools to further understand pathogenesis of this elusive pathogen.

引用

页码：27 / 31

页数：5

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