Construction of a family of biphenyl combinatorial libraries: Structure-activity studies utilizing libraries of mixtures

被引：25

作者：

Neustadt, BR ^{[1
]}

Smith, EM ^{[1
]}

Lindo, N ^{[1
]}

Nechuta, T ^{[1
]}

Bronnenkant, A ^{[1
]}

Wu, A ^{[1
]}

Armstrong, L ^{[1
]}

Kumar, C ^{[1
]}

机构：

[1] Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(98)00433-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A set of biphenyl aminoacid building blocks has been synthesized. These were used to construct partially-peptidic combinatorial libraries as equimolar multi-component samples. Activity of members of this library as vitronectin receptor antagonists is described, together with SAR studies of the most active members. These studies illustrate several important features of combinatorial libraries. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2395 / 2398

页数：4

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