Standardization and statistical approaches to therapeutic trials in the R6/2 mouse

被引：110

作者：

Hockly, E ^{[1
]}

Woodman, B ^{[1
]}

Mahal, A ^{[1
]}

Lewis, CM ^{[1
]}

Bates, G ^{[1
]}

机构：

[1] Univ London Kings Coll, Guys Hosp, Dept Med & Mol Genet, London SE1 9RT, England

来源：

BRAIN RESEARCH BULLETIN | 2003年 / 61卷 / 05期

基金：

英国医学研究理事会;

关键词：

Huntington's disease; mouse models; preclinical trials; behavior; statistical analysis;

D O I：

10.1016/S0361-9230(03)00185-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The R6/2 mouse is the most widely used animal model of Huntington's disease (HD), a genetic disorder causing movement disorders, personality changes, dementia, and premature death, for which there is currently no effective therapy. Use of animal models to assess novel therapeutic approaches to HD is Currently a major focus of research. Progress in this field will depend upon careful standardization of experimental protocols, and a sophisticated statistical approach. Here we investigate the sources of phenotypic variability in R6/2, and make recommendations for the future use of such models in therapeutic trials. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：469 / 479

页数：11

共 31 条

[1] [Anonymous], 2002, Huntington's disease
[2] Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and pallidoluysian atrophy: Correlation between the density of inclusions and IT15 CAG triplet repeat length
Becher, MW
Kotzuk, JA
Sharp, AH
Davies, SW
Bates, GP
Price, DL
Ross, CA
[J]. NEUROBIOLOGY OF DISEASE, 1998, 4 (06) : 387 - 397
[3] Controlling the false discovery rate in behavior genetics research
Benjamini, Y
Drai, D
Elmer, G
Kafkafi, N
Golani, I
[J]. BEHAVIOURAL BRAIN RESEARCH, 2001, 125 (1-2) : 279 - 284
[4] Bonferroni C. E., 1936, TEORIA STAT CLASSI C
[5] Carter RJ, 1999, J NEUROSCI, V19, P3248
[6] Carter RJ, 2000, MOVEMENT DISORD, V15, P925, DOI 10.1002/1531-8257(200009)15:5<925::AID-MDS1025>3.0.CO
[7] 2-Z
[8] Clark HB, 1997, J NEUROSCI, V17, P7385
[9] Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
Davies, SW
Turmaine, M
Cozens, BA
DiFiglia, M
Sharp, AH
Ross, CA
Scherzinger, E
Wanker, EE
Mangiarini, L
Bates, GP
[J]. CELL, 1997, 90 (03) : 537 - 548
[10] Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
DiFiglia, M
Sapp, E
Chase, KO
Davies, SW
Bates, GP
Vonsattel, JP
Aronin, N
[J]. SCIENCE, 1997, 277 (5334) : 1990 - 1993

← 1 2 3 4 →