A biocompatible process to prepare hyaluronan-based material able to self-assemble into stable nano-particles

被引：13

作者：

Calce, Enrica ^{[1
]}

Ringhieri, Paola ^{[2
]}

Mercurio, Flavia Anna ^{[1
]}

Leone, Marilisa ^{[1
,2
]}

Bugatti, Valeria ^{[3
]}

Saviano, Michele ^{[4
]}

Vittoria, Vittoria ^{[3
]}

De Luca, Stefania ^{[1
,2
]}

机构：

[1] CNR, Inst Biostruct & Bioimaging, I-80138 Naples, Italy

[2] Univ Naples Federico II, Interuniv Ctr Res Bioact Peptides CIRPeB, Dept Pharm, Naples, Italy

[3] Univ Salerno, Dept Ind Engn, I-84084 Fisciano, Sa, Italy

[4] CNR, Inst Crystallog, I-70126 Bari, Italy

来源：

RSC ADVANCES | 2015年 / 5卷 / 37期

关键词：

TARGETED DELIVERY; MODIFIED PECTIN; DRUG-DELIVERY; BROAD RANGE; ACID; NANOPARTICLES; NANOSYSTEMS; DERIVATIVES; COPOLYMERS; DOCETAXEL;

D O I：

10.1039/c5ra03107a

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

New self-assembled nano-particles were developed by chemical conjugation of natural fatty acids to the backbone of hyaluronan (HA). The chemical structure and the self-association behavior of them were studied by FT-IR, NMR, fluorescence and dynamic light scattering. The HA derivatives form stable spherical shape aggregates, as assessed by transmission electron microscopy.

引用

页码：29573 / 29576

页数：4

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