Monocyte count is a predictor of novel plaque formation - A 7-year follow-up study of 2610 persons without carotid plaque at baseline - The Tromso Study

被引:119
作者
Johnsen, SH [1 ]
Fosse, E
Joakimsen, O
Mathiesen, EB
Stensland-Bugge, E
Njolstad, I
Arnesen, E
机构
[1] Univ Tromso, Inst Community Med, N-9037 Tromso, Norway
[2] Univ Hosp No Norway, Dept Neurol, Tromso, Norway
关键词
atherosclerosis; inflammation; intima-media thickness; risk factors; ultrasonography;
D O I
10.1161/01.STR.0000158909.07634.83
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Purpose-Activation of monocytes and differentiation into lipid-laden macrophages are fundamental events in generation of atherosclerotic lesions. There exist few data on monocyte activity and the risk for atherosclerosis. In this prospective population-based study, we examined whether monocyte count in blood is a predictor of future plaque formation in persons without pre-existing carotid atherosclerosis. Methods-At baseline, we measured monocyte count, white cell count (WCC), fibrinogen, intima-media thickness (IMT), and traditional cardiovascular risk factors in 2610 men and women aged 25 to 82 years who on ultrasound had no plaque in their right carotid artery. After 7 years of follow-up, a new ultrasound screening was performed and the number of novel plaques was grouped as none, 1 plaque, and 2 or more plaques. Results-In multivariate analysis, monocyte count, age, sex, total cholesterol, current smoking, systolic blood pressure, and IMT were independent predictors of novel plaque formation. No significant association was found between plaque formation and either WCC or fibrinogen. For 1 standard deviation (0.17 x 10(9)) increase in monocyte count, the risk of being in a higher plaque category increased by 18% (OR, 1.18; 95% CI, 1.08 to 1.29). In the highest monocyte quartile, the risk for having plaque compared with the lowest quartile was 1.85 (OR) ( 95% confidence interval, 1.41 to 2.43). Repeating the analysis without IMT did not change the monocyte estimate. Excluding subjects with cardiovascular disease and diabetes mellitus from analysis neither changed the monocyte estimate. Conclusion-Monocyte count is an independent predictor of future plaque formation in subjects without pre-existing carotid atherosclerosis.
引用
收藏
页码:715 / 719
页数:5
相关论文
共 24 条
[1]   CAROTID INTIMA-MEDIA WALL THICKNESS IN ELDERLY WOMEN WITH AND WITHOUT ATHEROSCLEROSIS OF THE ABDOMINAL-AORTA [J].
BOTS, ML ;
WITTEMAN, JCM ;
GROBBEE, DE .
ATHEROSCLEROSIS, 1993, 102 (01) :99-105
[2]   Common carotid intima-media thickness and risk of stroke and myocardial infarction - The Rotterdam Study [J].
Bots, ML ;
Hoes, AW ;
Koudstaal, PJ ;
Hofman, A ;
Grobbee, DE .
CIRCULATION, 1997, 96 (05) :1432-1437
[3]   Monocyte count, but not C-reactive protein or interleukin-6, is an independent risk marker for subclinical carotid atherosclerosis [J].
Chapman, CML ;
Beilby, JP ;
McQuillan, BM ;
Thompson, PL ;
Hung, J .
STROKE, 2004, 35 (07) :1619-1624
[4]   Relation between hemostatic variables and increase of common carotid intima-media thickness in patients with peripheral arterial disease [J].
Cortellaro, M ;
Baldassarre, D ;
Cofrancesco, E ;
Tremoli, E ;
Colombo, A ;
Boschetti, C ;
Paoletti, R .
STROKE, 1996, 27 (03) :450-454
[5]   Tumor necrosis factor receptor levels are associated with carotid atherosclerosis [J].
Elkind, MS ;
Cheng, JF ;
Boden-Albala, B ;
Rundek, T ;
Thomas, J ;
Chen, H ;
Rabbani, LE ;
Sacco, RL .
STROKE, 2002, 33 (01) :31-37
[6]   Elevated white blood cell count and carotid plaque thickness - The Northern Manhattan Stroke Study [J].
Elkind, MS ;
Cheng, JF ;
Boden-Albala, B ;
Paik, MC ;
Sacco, RL .
STROKE, 2001, 32 (04) :842-849
[7]   ASSOCIATION OF HEMOSTATIC VARIABLES WITH PREVALENT CARDIOVASCULAR-DISEASE AND ASYMPTOMATIC CAROTID-ARTERY ATHEROSCLEROSIS [J].
FOLSOM, AR ;
WU, KK ;
SHAHAR, E ;
DAVIS, CE .
ARTERIOSCLEROSIS AND THROMBOSIS, 1993, 13 (12) :1829-1836
[8]   MECHANISMS OF DISEASE - THE PATHOGENESIS OF CORONARY-ARTERY DISEASE AND THE ACUTE CORONARY SYNDROMES .1. [J].
FUSTER, V ;
BADIMON, L ;
BADIMON, JJ ;
CHESEBRO, JH .
NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (04) :242-250
[9]   Emerging risk factors for atherosclerotic vascular disease - A critical review of the evidence [J].
Hackam, DG ;
Anand, SS .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 290 (07) :932-940
[10]   CAROTID ATHEROSCLEROSIS MEASURED BY B-MODE ULTRASOUND IN POPULATIONS - ASSOCIATIONS WITH CARDIOVASCULAR RISK-FACTORS IN THE ARIC STUDY [J].
HEISS, G ;
SHARRETT, AR ;
BARNES, R ;
CHAMBLESS, LE ;
SZKLO, M ;
ALZOLA, C .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1991, 134 (03) :250-256