Regulation of mature T cell homeostasis

被引：169

作者：

Surh, CD ^{[1
]}

Sprent, J ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

来源：

SEMINARS IN IMMUNOLOGY | 2005年 / 17卷 / 03期

关键词：

homeostasis; T cells; cytokines;

D O I：

10.1016/j.smim.2005.02.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The overall size and the composition of the mature T cell pool are regulated by homeostatic mechanisms. Recent work has revealed that homeostatic signals are received from contact with two members of the common gamma chain family of cytokines, IL-7 and IL-15, and from self-MHC/peptide ligands. In essence, homeostasis of naive T cells is regulated by IL-7 and self-MHC/peptide ligands and homeostasis of memory CD8 cells is controlled by IL-7 and IL-15. All of these signals also appear to be important to a varying degree for homeostasis of memory CD4 cells, but the details are less well understood than for other cell type. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：183 / 191

页数：9

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