Glycosylation regulates notch signalling

被引：326

作者：

Haines, N

Irvine, KD ^{[1
]}

机构：

[1] Rutgers State Univ, Waksman Inst, Howard Hughes Med Inst, Piscataway, NJ 08854 USA

[2] Rutgers State Univ, Dept Mol Biol & Biochem, Piscataway, NJ 08854 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm1228

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Intracellular post-translational modifications such as phosphorylation and ubiquitylation have keen well studied for their roles in regulating diverse signalling pathways, but we are only just beginning to understand hove differential glycosylation is used to regulate intercellular signalling. Recent studies make clear that extracellular post-translational modifications, in the form of glycosylation, are essential for the Notch signalling pathway, and that differences in the extent of glycosylation are a significant mechanism by which this pathway is regulated.

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收藏

页码：786 / 797

页数：12

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