Polymer-caged lipsomes: A pH-Responsive delivery system with high stability

被引：197

作者：

Lee, Sang-Min ^{[1
]}

Chen, Haimei ^{[1
]}

Dettmer, Christine M. ^{[1
]}

O'Halloran, Thomas V. ^{[1
]}

Nguyen, Sonlinh T. ^{[1
]}

机构：

[1] Northwestern Univ, Ctr Canc Nanotechnol Excellence, Dept Chem, Evanston, IL 60208 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 49期

关键词：

D O I：

10.1021/ja070748i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polymer-incorporated liposomes were prepared from preformed liposomes and a cholesterol-functionalized poly(acrylic acid) additive via a simple drop-in procedure. These modified liposomes possess surface-active carboxylate groups that can be cross-linked with telechelic 2,2'-(ethylenedioxy)bis(ethylamine) linkers, resulting in polymer-caged liposomes (PCLs) that are highly stable and have tunable pH-sensitive responses.

引用

页码：15096 / +

页数：3

共 22 条

[1] Controlled destabilization of a liposomal drug delivery system enhances mitoxantrone antitumor activity [J].

Adlakha-Hutcheon, G ;

Bally, MB ;

Shew, CR ;

Madden, TD .

NATURE BIOTECHNOLOGY, 1999, 17 (08) :775-779

[2] SERUM-INDUCED LEAKAGE OF LIPOSOME CONTENTS [J].

ALLEN, TM ;

CLELAND, LG .

BIOCHIMICA ET BIOPHYSICA ACTA, 1980, 597 (02) :418-426

[3] Development of a universal alkoxyamine for "living" free radical polymerizations [J].

Benoit, D ;

Chaplinski, V ;

Braslau, R ;

Hawker, CJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (16) :3904-3920

[4] Multifunctional polymeric nanoparticles from diverse bioactive agents [J].

Bertin, PA ;

Gibbs, JM ;

Shen, CKF ;

Thaxton, CS ;

Russin, WA ;

Mirkin, CA ;

Nguyen, ST .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (13) :4168-4169

[5] GRAFT-COPOLYMERS THAT EXHIBIT TEMPERATURE-INDUCED PHASE-TRANSITIONS OVER A WIDE-RANGE OF PH [J].

CHEN, GH ;

HOFFMAN, AS .

NATURE, 1995, 373 (6509) :49-52

[6] Lipid encapsulation of arsenic trioxide attenuates cytotoxicity and allows for controlled anticancer drug release [J].

Chen, Haimei ;

MacDonald, Robert C. ;

Li, Shuyou ;

Krett, Nancy L. ;

Rosen, Steven T. ;

O'Halloran, Thomas V. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (41) :13348-13349

[7] Synthesis and characterization of novel aromatic azo bond-containing pH-sensitive and hydrolytically cleavable IPN hydrogels [J].

Chivukula, P ;

Dusek, K ;

Wang, D ;

Dusková-Smrcková, M ;

Kopecková, P ;

Kopecek, J .

BIOMATERIALS, 2006, 27 (07) :1140-1151

[8] pH-Sensitive, cation-selective channels formed by a simple synthetic polyelectrolyte in artificial bilayer membranes [J].

Chung, JC ;

Gross, DJ ;

Thomas, JL ;

Tirrell, DA ;

OpsahlOng, LR .

MACROMOLECULES, 1996, 29 (13) :4636-4641

[9] Interaction between a novel amphiphilic polymer and liposomes [J].

Hara, M ;

Miyake, M ;

Iijima, S ;

Yang, Q ;

Arai, T ;

Yuan, HQ ;

Miyake, J .

SUPRAMOLECULAR SCIENCE, 1998, 5 (5-6) :777-781

[10] Poly(ethylene glycol)-lipid conjugates regulate the calcium-induced fusion of liposomes composed of phosphatidylethanolamine and phosphatidylserine [J].

Holland, JW ;

Hui, C ;

Cullis, PR ;

Madden, TD .

BIOCHEMISTRY, 1996, 35 (08) :2618-2624

← 1 2 3 →