Arterial stiffness: clinical relevance, measurement and treatment

被引：184

作者：

Hamilton, Paul K. ^{[1
]}

Lockhart, Christopher J. ^{[1
]}

Quinn, Cathy E. ^{[1
]}

McVeigh, Gary E. ^{[1
]}

机构：

[1] Queens Univ Belfast, Dept Therapeut & Pharmacol, Belfast BT9 7BL, Antrim, North Ireland

来源：

CLINICAL SCIENCE | 2007年 / 113卷 / 3-4期

关键词：

arterial mechanics; arterial stiffness; augmentation index; cardiovascular risk factor; pulse pressure; pulse wave velocity;

D O I：

10.1042/CS20070080

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Most traditional cardiovascular risk factors alter the structure and/or function of arteries. An assessment of arterial wall integrity could therefore allow accurate prediction of cardiovascular risk in individuals. The term 'arterial stiffness' denotes alterations in the mechanical properties of arteries, and much effort has focused on how best to measure this. Pulse pressure, pulse wave velocity, pulse waveform analysis, localized assessment of blood vessel mechanics and other methods have all been used. We review the methodology underlying each of these measures, and present an evidence-based critique of their relative merits and limitations. An overview is also given of the drug therapies that may prove useful in the treatment of patients with altered arterial mechanics.

引用

页码：157 / 170

页数：14

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