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Getting the mOST from OST: Role of organic solute transporter, OSTα-OSTβ, in bile acid and steroid metabolism

被引：86
作者：
Dawson, Paul A. [1 ]
Hubbert, Melissa L. [1 ]
Rao, Anuradha [1 ]
机构：
[1] Wake Forest Univ, Dept Internal Med, Sch Med, Gastroenterol Sect, Winston Salem, NC 27157 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2010年 / 1801卷 / 09期
基金：
美国国家卫生研究院;
关键词：
Bile acids; Transporter; Enterocyte; Hepatocyte; Enterohepatic circulation; Malabsorption; Cholestasis; Adrenal; Steroid hormones; HEPATOCYTE NUCLEAR FACTOR-1-ALPHA; RESISTANCE-ASSOCIATED PROTEIN-3; CHOLESTEROL; 7-ALPHA-HYDROXYLASE; RENAL EXCRETION; OBSTRUCTIVE CHOLESTASIS; HEPATOBILIARY TRANSPORT; TAUROCHOLATE TRANSPORT; CELLULAR-LOCALIZATION; GENE-TRANSCRIPTION; ADAPTIVE RESPONSE;
D O I：
10.1016/j.bbalip.2010.06.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要：
The organic solute transporter (OST)(alpha)-OST(beta) is an unusual heteromeric carrier expressed in a variety of tissues including the small intestine, colon, liver, biliary tract, kidney, and adrenal gland. In polarized epithelial cells. OST alpha-OST beta protein is localized on the basolateral membrane and functions in the export or uptake of bile acids and steroids. This article reviews recent results including studies of knockout mouse models that provide new insights to the role of OST alpha-OST beta in the compartmentalization and metabolism of these important lipids. (C) 2010 Elsevier B.V. All rights reserved.
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收藏
页码：994 / 1004
页数：11
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