Palladium and Raney nickel catalyzed methanolic cleavage of stable borane-amine complexes

被引：87

作者：

Couturier, M ^{[1
]}

Tucker, JL ^{[1
]}

Andresen, BM ^{[1
]}

Dubé, P ^{[1
]}

Negri, JT ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, Proc Res & Dev, Groton, CT 06340 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 03期

关键词：

D O I：

10.1021/ol006969+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Palladium and Raney nickel were found to catalyze the methanolysis of borane-amine adducts, Hence, strongly complexed amines can now be liberated by simple treatment with Pd/C or Raney Ni in methanol, The method is applicable to primary, secondary, tertiary, and aromatic amines, and the mildness of the reaction conditions allows preservation of otherwise labile functional groups.

引用

页码：465 / 467

页数：3

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