Chronic activation of ERK and neurodegenerative diseases

被引:186
作者
Colucci-D'Amato, L
Perrone-Capano, C
di Porzio, U
机构
[1] CNR, Inst Endocrinol & Expt Oncol, I-80131 Naples, Italy
[2] Univ Catanzaro Magno Grecia, Fac Pharm, Roccelletta Di Borgia, CZ, Italy
[3] CNR, Inst Genet & Biophys Adriano Buzzati Traverso, Naples, Italy
关键词
D O I
10.1002/bies.10355
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The extracellular-signal regulated kinases 1/2 (ERK or ERKs) are involved in the regulation of important neuronal functions, including neuronal plasticity in normal and pathological conditions. We present findings that support the notion that the kinetics and localization of ERK are intrinsically linked, in that the duration of ERK activation dictates its subcellular compartmentalization and/or trafficking. The latter, in turn, dictates whether ERK-expressing cells would enter a program of cell death, survival or differentiation. We summarize experimental data showing that chronic activation of ERK plays a role in the mechanisms that trigger neurodegeneration. We also discuss how MKPs, members of the subclass of dual specificity phosphatases, might be the link between ERK kinetics and its subcellular localization. (C) 2003 Wiley Periodicals, Inc.
引用
收藏
页码:1085 / 1095
页数:11
相关论文
共 89 条
[1]   Molecular psychology: Roles for the ERK MAP kinase cascade in memory [J].
Adams, JP ;
Sweatt, JD .
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2002, 42 :135-163
[2]   GDNF family neurotrophic factor signaling: Four masters, one servant? [J].
Airaksinen, MS ;
Titievsky, A ;
Saarma, M .
MOLECULAR AND CELLULAR NEUROSCIENCE, 1999, 13 (05) :313-325
[3]   MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia [J].
Alessandrini, A ;
Namura, S ;
Moskowitz, MA ;
Bonventre, JV .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (22) :12866-12869
[4]   The MAPK cascade is required for mammalian associative learning [J].
Atkins, CM ;
Selcher, JC ;
Petraitis, JJ ;
Trzaskos, JM ;
Sweatt, JD .
NATURE NEUROSCIENCE, 1998, 1 (07) :602-609
[5]   STIMULATION OF PROTEIN TYROSINE PHOSPHORYLATION BY NMDA RECEPTOR ACTIVATION [J].
BADING, H ;
GREENBERG, ME .
SCIENCE, 1991, 253 (5022) :912-914
[6]  
Ballif BA, 2001, CELL GROWTH DIFFER, V12, P397
[7]   THE EFFECT OF FETAL MESENCEPHALON IMPLANTS ON PRIMATE MPTP-INDUCED PARKINSONISM - HISTOCHEMICAL AND BEHAVIORAL-STUDIES [J].
BANKIEWICZ, KS ;
PLUNKETT, RJ ;
JACOBOWITZ, DM ;
PORRINO, L ;
DIPORZIO, U ;
LONDON, WT ;
KOPIN, IJ ;
OLDFIELD, EH .
JOURNAL OF NEUROSURGERY, 1990, 72 (02) :231-244
[8]   MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network [J].
Bhalla, US ;
Ram, PT ;
Iyengar, R .
SCIENCE, 2002, 297 (5583) :1018-1023
[9]   Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism [J].
Bonifati, V ;
Rizzu, P ;
van Baren, MJ ;
Schaap, O ;
Breedveld, GJ ;
Krieger, E ;
Dekker, MCJ ;
Squitieri, F ;
Ibanez, P ;
Joosse, M ;
van Dongen, JW ;
Vanacore, N ;
van Swieten, JC ;
Brice, A ;
Meco, G ;
van Duijn, CM ;
Oostra, BA ;
Heutink, P .
SCIENCE, 2003, 299 (5604) :256-259
[10]  
Brami-Cherrier K, 2002, J NEUROSCI, V22, P8911