The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow

被引：82

作者：

Siggs, Owen M. ^{[1
]}

Arnold, Carrie N. ^{[1
]}

Huber, Christoph ^{[2
]}

Pirie, Elaine ^{[1
]}

Xia, Yu ^{[1
]}

Lin, Pei ^{[1
]}

Nemazee, David ^{[2
]}

Beutler, Bruce ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Genet, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

来源：

NATURE IMMUNOLOGY | 2011年 / 12卷 / 05期

基金：

美国国家卫生研究院; 比尔及梅琳达.盖茨基金会;

关键词：

P-TYPE ATPASES; CELL-DEVELOPMENT; LYMPHOCYTE-ACTIVATION; ANTIBODY-RESPONSES; ENU MUTAGENESIS; IL-7; RECEPTOR; PRO-B; MICE; EXPRESSION; INTERLEUKIN-7;

D O I：

10.1038/ni.2012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

B lymphopoiesis begins in the fetal liver, switching after birth to the bone marrow, where it persists for life. The unique developmental outcomes of each phase are well documented, yet their molecular requirements are not. Here we describe two allelic X-linked mutations in mice that caused cell-intrinsic arrest of adult B lymphopoiesis. Mutant fetal liver progenitors generated B cells in situ but not in irradiated adult bone marrow, which emphasizes a necessity for the affected pathway only in the context of adult bone marrow. The causative mutations were ascribed to Atp11c, which encodes a P4-type ATPase with no previously described function. Our data establish an essential, cell-autonomous and context-sensitive function for ATP11C, a putative aminophospholipid flippase, in B cell development.

引用

页码：434 / U89

页数：8

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