The Role of the Transcription Factor CREB in Immune Function

被引：628

作者：

Wen, Andy Y. ^{[2
]}

Sakamoto, Kathleen M. ^{[3
]}

Miller, Lloyd S. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Div Dermatol, Dept Med, David Geffen Sch Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Div Pediat Crit Care, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Pediat, Div Pediat Hematol & Oncol, Los Angeles, CA 90024 USA

来源：

JOURNAL OF IMMUNOLOGY | 2010年 / 185卷 / 11期

基金：

美国国家卫生研究院;

关键词：

ELEMENT-BINDING PROTEIN; REGULATORY T-CELLS; NF-KAPPA-B; HUMAN MONOCYTIC CELLS; AMP RESPONSE ELEMENT; GLYCOGEN-SYNTHASE KINASE-3; FOXP3; GENE-EXPRESSION; MEDIATED TRANSCRIPTION; MACROPHAGE APOPTOSIS; SIGNALING PATHWAYS;

D O I：

10.4049/jimmunol.1001829

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CREB is a transcription factor that regulates diverse cellular responses, including proliferation, survival, and differentiation. CREB is induced by a variety of growth factors and inflammatory signals and subsequently mediates the transcription of genes containing a cAMP-responsive element. Several immune-related genes possess this cAMP-responsive element, including IL-2, IL-6, IL-10, and TNF-alpha. In addition, phosphorylated CREB has been proposed to directly inhibit NF-kappa B activation by blocking the binding of CREB binding protein to the NF-kappa B complex, thereby limiting proinflammatory responses. CREB also induces an antiapoptotic survival signal in monocytes and macrophages. In T and B cells, CREB activation promotes proliferation and survival and differentially regulates Th1, Th2, and Th17 responses. Finally, CREB activation is required for the generation and maintenance of regulatory T cells. This review summarizes current advances involving CREB in immune function-a role that is continually being defined. The Journal of Immunology, 2010, 185: 6413-6419.

引用

页码：6413 / 6419

页数：7

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