Levels of matrix metalloproteinase-1 and tissue inhibitors of metalloproteinase-1 in gastric cancer

被引：45

作者：

Kemik, Ozgur ^{[1
]}

Kemik, Ahu Sarbay ^{[2
]}

Sumer, Aziz ^{[1
]}

Dulger, Ahmet Cumhur ^{[3
]}

Adas, Mine ^{[4
]}

Begenik, Huseyin ^{[5
]}

Hasirci, Ismail ^{[1
]}

Yilmaz, Ozkan ^{[1
]}

Purisa, Sevim ^{[6
]}

Kisli, Erol ^{[1
]}

Tuzun, Sefa ^{[7
]}

Kotan, Cetin ^{[1
]}

机构：

[1] Yuzuncu Yil Univ, Fac Med, Dept Gen Surg, TR-6500 Van, Turkey

[2] Istanbul Univ, Cerrahpasa Med Fac, Dept Biochem, TR-3400 Istanbul, Turkey

[3] Yuzuncu Yil Univ, Fac Med, Dept Gastroenterol, TR-6500 Van, Turkey

[4] Okmeydani Educ & Res Hosp, Dept Endocrinol, TR-3400 Istanbul, Turkey

[5] Yuzuncu Yil Univ, Fac Med, Dept Internal Med, TR-6500 Van, Turkey

[6] Istanbul Univ, Istanbul Fac Med, Dept Biostat, TR-3400 Istanbul, Turkey

[7] Haseki Educ & Res Hosp, TR-3400 Istanbul, Turkey

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2011年 / 17卷 / 16期

关键词：

Gastric cancer; Matrix metalloproteinase-1; Tissue matrix metalloproteinase-1; COLORECTAL-CANCER; SERUM-LEVELS; EXPRESSION; TIMP-1; CARCINOMA; INVASION; COLLAGEN; DISEASES; ROLES; MMP-9;

D O I：

10.3748/wjg.v17.i16.2109

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

AIM: To evaluate the levels of preoperative serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in gastric cancer. METHODS: One hundred gastric cancer patients who underwent gastrectomy were enrolled in this study. The serum concentrations of MMP-1 and TIMP-1 in these patients and in fifty healthy controls were determined using an enzyme-linked immunosorbent assay. RESULTS: Higher serum MMP-1 and TIMP-1 levels were observed in patients than in controls (P < 0.001). Serum MMP-1 and TIMP-1 levels were positively associated with morphological appearance, tumor size, depth of wall invasion, lymph node metastasis, liver metastasis, perineural invasion, and pathological stage. They were not significantly associated with age, gender, tumor location, or histological type. CONCLUSION: Increased MMP-1 and TIMP-1 were associated with gastric cancer. Although these markers are not good markers for diagnosis, these markers show in advanced gastric cancer. (C) 2011 Baishideng. All rights reserved.

引用

页码：2109 / 2112

页数：4

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