Highly-sensitive determination of 6-mercaptopurine and its metabolites by electrochemical reductive desorption measurements

被引：17

作者：

Sato, Y

Ishikawa, Y

Matsuura, H

Uosaki, K

Mizutani, F

Niwa, O

机构：

[1] Natl Inst Adv Ind Sci & Technol, Tsukuba, Ibaraki 3058566, Japan

[2] Hokkaido Univ, Grad Sch Sci, Div Chem, Chem Phys Lab, Sapporo, Hokkaido 0600810, Japan

[3] Univ Tsukuba, Dept Chem, Tsukuba, Ibaraki 3058571, Japan

来源：

ELECTROANALYSIS | 2005年 / 17卷 / 11期

关键词：

6-mercaptopurine; gold electrode; self-assembled monolayer; chemisorption; accumulation;

D O I：

10.1002/elan.200403165

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The electrochemical detection of 6-mercaputopurine (6-MP), which is one of the most well-known drugs of antimetabolites, and its analogues was studied. The presented method is based on chemisorption (accumulation)/desorption processes of drugs onto/from the An electrode surface. Using this method, we succeeded in detecting 6-MP even in very diluted solution (concentration of 6-MP: 1 x 10(-8) M). The lower detection limit of 6-MP was considerably improved compared with the previous HPLC studies by using our proposed system. Desorptive potentials of 6-MP-metabolites and its analogues were different from those of 6-MP. This provides the possibility of simultaneous detection of 6-MP and its typical metabolites.

引用

页码：965 / 968

页数：4

共 26 条

[1] Electrochemical desorption of binary self-assembled monolayers of butyl hexadecyl disulfide on Au(111) electrodes [J].