Genetic abnormalities and male infertility. A comprehensive review.

被引：30

作者：

Thielemans, BFJ

Spiessens, C

D'Hooghe, T

Vanderschueren, D

Legius, E

机构：

[1] Univ Hosp Gasthuisberg, Leuven Univ, Fertil Ctr, B-3000 Louvain, Belgium

[2] Univ Hosp Gasthuisberg, Dept Endocrinol, B-3000 Louvain, Belgium

[3] Univ Hosp Gasthuisberg, Ctr Human Genet, B-3000 Louvain, Belgium

来源：

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 1998年 / 81卷 / 02期

关键词：

male infertility; SRY; AZF; microdeletions; Y chromosome; spermatogenesis;

D O I：

10.1016/S0301-2115(98)00194-8

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The development of assisted reproductive technologies, such as intracytoplasmic sperm injection (ICSI) substantially improved the outlook for patients with severe male fertility problems. However this implies that for the first time genetic defects associated with male in- or subfertility might be transmitted to offspring and result in genetic disease [de Kretser DM, The potential of intracytoplasmic sperm injection (ICSI) to transmit genetic defects causing male infertility. Reprod Fertil Dev 1995;7:137-142]. The knowledge of male specific fertility genes on the Y chromosome increased enormously in the last decade. The SRY gene plays a critical role in gonadal differentiation. DAZ, SPGY and related genes on the Y chromosome are very important for spermatogenesis. Interstitial Y-chromosomal microdeletions encompassing the AZFa, b or c region have become an additional class of genetic abnormalities causing male infertility. A review is given of the different genetic aspects of male infertility. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：217 / 225

页数：9

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