Synthesis of pyrrolopyrimidine CRF-R1 antagonists containing a tricyclic core via an intramolecular heck reaction

被引：4

作者：

Dyck, B ^{[1
]}

McCarthy, JR ^{[1
]}

机构：

[1] Neurocrine Biosci Inc, Dept Med Chem, San Diego, CA 92121 USA

来源：

HETEROCYCLES | 2004年 / 62卷

关键词：

corticotropin-releasing factor (hormone); fused pyrimidine; anxiety; depression;

D O I：

10.3987/COM-03-S(P)41

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthetic route to pharmaceutically important tricyclic pyrrolopyrimidines was developed. The method employs a palladium-mediated Heck cyclization as the critical step in the construction of the final six membered ring.

引用

页码：191 / 195

页数：5

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