Diet, genetic susceptibility and human cancer etiology

被引：28

作者：

Sinha, R ^{[1
]}

Caporaso, N ^{[1
]}

机构：

[1] NCI, Div Canc Epidemiol & Genet, NIH, Rockville, MD 20892 USA

来源：

JOURNAL OF NUTRITION | 1999年 / 129卷 / 02期

关键词：

heterocyclic amines; cytochrome P4501A2; N-acetyltransferase; MelQx; genotype; phenotype; inducible;

D O I：

10.1093/jn/129.2.556S

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

There is evidence that high penetrance hereditary genes cause a number of relatively uncommon tumors in the familial setting, whereas common cancers are influenced by multiple loci that alter susceptibility to cancer and other conditions. The latter category of genes are involved in the metabolism of carcinogens (activation, detoxification) as well as those that interact with dietary exposure. This paper will consider some of the basic principles in studying susceptibility genes and provide a few examples in which they interact with dietary components.

引用

页码：556S / 559S

页数：4

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