Traumatic subarachnoid hemorrhage and its treatment with nimodipine

被引：150

作者：

Harders, A

Kakarieka, A

Braakman, R

Hardenack, M

Schmieder, K

Trost, HA

Hellwig, H

Buchholz, EM

Klein, T

Peters, R

Zierski, J

Veelken, J

Gilsbach, JM

Mayfrank, L

Bassiouni, H

Brawanski, A

Holzschuh, M

Hassler, WE

Rohde, V

Ziebell, P

Emonds, N

Markakis, E

Kolenda, H

Zimmerer, B

Scharphuis, T

Eggert, HR

Wilkowski, A

May, JW

Faulhauer, K

Lauer, J

Paulus, J

Schoche, J

Raabe, A

Salger, D

Schibalski, G

Burkert, W

Rainov, N

Heidecke, V

Hamm, K

Grote, EH

Buchholz, R

Morgalla, M

Meinig, G

Leyendecker, K

Schuerhoff, W

Wassmann, D

Moskopp, D

vonWild, K

Schutze, M

Schonmayr, R

机构：

[1] BAYER AG, CNS CLIN RES, COLOGNE, GERMANY

[2] ERASMUS UNIV ROTTERDAM, DEPT NEUROSURG, ROTTERDAM, NETHERLANDS

[3] UNIV KLIN BOCHUM, BOCHUM, GERMANY

[4] UNIV ESSEN GESAMTHSCH KLINIKUM, W-4300 ESSEN, GERMANY

[5] KRANKENHAUS MERHEIM, COLOGNE, GERMANY

[6] KRANKENHAUS BERLIN NEUKOLLN, BERLIN, GERMANY

[7] RHEIN WESTFAL TH AACHEN, W-5100 AACHEN, GERMANY

[8] UNIV REGENSBURG, W-8400 REGENSBURG, GERMANY

[9] STADT KLINIKEN, DUISBURG, GERMANY

[10] UNIV GOTTINGEN, W-3400 GOTTINGEN, GERMANY

[11] STADT KLINIKEN, DORTMUND, GERMANY

[12] STADT KLINIKEN, KASSEL, GERMANY

[13] KRANKENHAUS BARMHERZIGEN BRUDER, TRIER, GERMANY

[14] STADT KLINIKEN, CHEMNITZ, GERMANY

[15] KLINIKUM SCHWERIN, SCHWERIN, GERMANY

[16] UNIV HALLE WITTENBERG, HALLE, GERMANY

[17] MED HSCH, ERFURT, GERMANY

[18] UNIV KLINIKEN, TUBINGEN, GERMANY

[19] UNFALLKLIN FRANKFURT, FRANKFURT, GERMANY

[20] UNIV MUNSTER, W-4400 MUNSTER, GERMANY

[21] CLEMENS HOSP, MUNSTER, GERMANY

[22] HORST SCHMIDT KLINIKEN, WIESBADEN, GERMANY

[23] STADT KLINIKUM, FULDA, GERMANY

[24] KNAPPSCHAFTS KRANKENHAUS, BOCHUM, GERMANY

[25] UNIV ROTTERDAM HOSP, ROTTERDAM, NETHERLANDS

来源：

JOURNAL OF NEUROSURGERY | 1996年 / 85卷 / 01期

关键词：

head injury; subarachnoid hemorrhage; computerized tomography; vasospasm; nimodipine; clinical trial;

D O I：

10.3171/jns.1996.85.1.0082

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A prospective. randomized, double-blind. placebo-controlled study of nimodipine used to treat traumatic subarachnoid hemorrhage (tSAH) was conducted in 21 German neurosurgical centers between January 1994 and April 1995. One hundred twenty-three patients with tSAH appearing on initial computerized tomography (CT) scanning were entered into the study. Requirements for inclusion included age between 16 and 70 and admission into the study within 12 hours after head injury, regardless of the patient's level of consciousness. Eligible patients received either a sequential course of intravenous and oral nimodipine or placebo treatment for 3 weeks. Patients were closely monitored using clinical neurology, computerized tomography, laboratory, and transcranial Doppler ultrasound parameters. Patients treated with nimodipine had a significantly less unfavorable outcome (death, vegetative survival, or severe disability) at 6 months than placebo-treated patients (25% us. 46%, p = 0.02). The relative reduction in unfavorable outcome in the nimodipine-treated group was even higher (55%, p = 0.002) when only patients who complied with the protocol were considered.

引用

页码：82 / 89

页数：8

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