A Hemin/G-Quadruplex Acts as an NADH Oxidase and NADH Peroxidase Mimicking DNAzyme

被引：148

作者：

Golub, Eyal ^{[1
,2
]}

Freeman, Ronit ^{[1
,2
]}

Willner, Itamar ^{[1
,2
]}

机构：

[1] Hebrew Univ Jerusalem, Inst Chem, IL-91904 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Ctr Nanosci & Nanotechnol, IL-91904 Jerusalem, Israel

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 49期

基金：

以色列科学基金会;

关键词：

DNAzymes; DNA structures; enzymes; G-quadruplexes; CATALYZED ORGANIC-SYNTHESIS; OXYGEN ACTIVATION; TELOMERIC DNA; REGENERATION; OXIDATION; SENSORS; BIOTRANSFORMATIONS; ELECTRODES; COMPLEXES; COFACTORS;

D O I：

10.1002/anie.201103853

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enzyme impressionist: A DNAzyme consisting of hemin combined with a G-quadruplex was shown to mimic the activity of NADH oxidase under aerobic conditions and of NADH peroxidase under anaerobic conditions. Along with these new biocatalytic activities, the hemin/G-quadruplex complex is also capable of regenerating the biologically important NAD+ cofactor in both cycles (see picture). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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页码：11710 / 11714

页数：5

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