Oncologic Results of Laparoscopic Versus Open Hepatectomy for Colorectal Liver Metastases in Two Specialized Centers

被引:224
作者
Castaing, Denis [1 ,2 ,3 ]
Vibert, Eric [1 ,2 ,3 ]
Ricca, Luana [1 ,4 ,5 ]
Azoulay, Daniel [1 ]
Adam, Rene [1 ]
Gayet, Brice [4 ,5 ]
机构
[1] Hop Paul Brousse, AP HP, Ctr Hepatobiliaire, F-94804 Villejuif, France
[2] INSERM, U785, F-94804 Villejuif, France
[3] Univ Paris 11, UMR S 785, Villejuif, France
[4] Inst Mutualiste Montsouris, Dept Digest Dis, F-75014 Paris, France
[5] Univ Paris 05, F-75006 Paris, France
关键词
HEPATIC RESECTION; CANCER; IRINOTECAN; FLUOROURACIL; SURVIVAL; SURGERY; OXALIPLATIN; LEUCOVORIN; PROPOSAL;
D O I
10.1097/SLA.0b013e3181bcaf63
中图分类号
R61 [外科手术学];
学科分类号
摘要
Objective: Compare oncologic results of laparoscopic versus open hepatectomy for resection of colorectal metastases to the liver. Summary and Background Data: Open hepatectomy (OH) is the current standard of care for the management of colorectal liver metastases. Although the feasibility of laparoscopic hepatectomy (LH) has been established, only select centers have used this technique as their primary modality. At present there is no study comparing the oncologic outcomes for colorectal liver metastases patients undergoing LH versus OH. Methods: Two groups composed of 60 patients each were obtained from 2 specialized liver units performing either OH or LH as their primary modality. Cohorts of 215 LH cases and 1783 OH were used to establish the study population. Patients were compared on an intention to treat basis using 9 preoperative prognostic criteria obtained from LiverMetSurvey. These included sex, age, primary tumor localization, number of tumors, diameter of tumor, distribution of metastases, presence of extrahepatic disease, initial respectability, and the use of prehepatectomy chemotherapy. Overall survival and disease-free survival were compared between OH and LH for a follow-up of 36 months. Results: The median follow-up for the LH group is 30 months and 33 months for the OH group (P = 0.75). One-, 3-, and 5-year patient survival for LH was 97%, 82%, and 64% and 97%, 70%, and 56% in the OH group, respectively (P = 0.32). One-, 3-, and 5-year disease-free survival was 70%, 47%, and 35% and 70%, 40%, and 27% (P = 0.32), respectively for the 2 groups. Conclusion: In a highly specialized center, first line application of laparoscopic liver resection in selected patients can provide comparable oncologic results to treatment with open liver resection for patients with colorectal liver metastases. (Ann Surg 2009;250: 849-855)
引用
收藏
页码:849 / 855
页数:7
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