Functional connections and pathways of coenzyme Q10-inducible genes:: an In-silico study

被引:47
作者
Doering, Frank
Schmelzer, Constance
Lindner, Inka
Vock, Christina
Fujii, Kenji
机构
[1] Univ Kiel, Inst Human Nutr & Food Sci, D-24118 Kiel, Germany
[2] Kaneka Corp, Funct Food Ingredients Div, Osaka, Japan
关键词
coenzyme Q(10); in-silico analysis; cardiovascular diseases;
D O I
10.1080/15216540701545991
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Coenzyme Q(10) (CoQ(10), ubiquinone) is an essential cofactor in the electron transport chain, serves as a potent antioxidant in mitochondria and lipid membranes, and is often used as a dietary supplement for a number of diseases including cardiovascular diseases. Recently, we obtained evidence that CoQ(10) ( Kaneka Q(10)(TM)) affects the expression of hundreds of human genes. To decipher the functional and regulatory connections of these genes, a literature search combined with transcription factor binding site analysis was performed using Genomatix BiblioSphere and MatInspector. This in-silico analysis revealed 17 CoQ(10)-inducible genes which are functionally connected by signalling pathways of G-protein coupled receptors, JAK/STAT, integrin, and beta-arrestin. Promoter analysis of these CoQ(10)-inducible genes showed one group of NF kappa B-regulated genes, namely IL5, thrombin, vitronectin receptor and C-reactive protein (CRP). Furthermore, a common promoter framework containing binding sites of the transcription factor families EVI1, HOXF, HOXC, and CLOX was identified in the promoters of IL5, CRP, and vitronectin receptor. The identi. ed CoQ(10)-inducible genes and pathways play an important role in inflammatory response. Since these effects are based on an in-vitro study, the effect of CoQ(10) on vascular health in vivo needs to be addressed in further animal and/or human intervention studies.
引用
收藏
页码:628 / 633
页数:6
相关论文
共 47 条
[1]  
ANDRES V, 1992, DEVELOPMENT, V116, P321
[2]   Coenzyme Q10 supplementation in infertile men with idiopathic asthenozoospermia:: an open, uncontrolled pilot study [J].
Balercia, G ;
Mosca, F ;
Mantero, F ;
Boscaro, M ;
Mancini, A ;
Ricciardo-Lamonica, G ;
Littarru, G .
FERTILITY AND STERILITY, 2004, 81 (01) :93-98
[3]   Coenzyme Q10 levels in idiopathic and varicocele-associated asthenozoospermia [J].
Balercia, G ;
Arnaldi, G ;
Fazioli, F ;
Serresi, M ;
Alleva, R ;
Mancini, A ;
Mosca, F ;
Lamonica, GR ;
Mantero, F ;
Littarru, GP .
ANDROLOGIA, 2002, 34 (02) :107-111
[4]   Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment [J].
Beal, MF .
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 2004, 36 (04) :381-386
[5]  
Beal MF, 2003, BIOFACTORS, V18, P153
[6]   Coenzyme Q10 and exercise training in chronic heart failure [J].
Belardinelli, Romualdo ;
Mucaj, Andi ;
Lacalaprice, Francesca ;
Solenghi, Maridia ;
Seddaiu, Giovanna ;
Principi, Federica ;
Tiano, Luca ;
Littarru, Gian Paolo .
EUROPEAN HEART JOURNAL, 2006, 27 (22) :2675-2681
[7]   Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome [J].
Berman, BP ;
Nibu, Y ;
Pfeiffer, BD ;
Tomancak, P ;
Celniker, SE ;
Levine, M ;
Rubin, GM ;
Eisen, MB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (02) :757-762
[8]   Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: A randomized, placebo-controlled study [J].
Berman, M ;
Erman, A ;
Ben-Gal, T ;
Dvir, D ;
Georghiou, GP ;
Stamler, A ;
Vered, Y ;
Vidne, BA ;
Aravot, D .
CLINICAL CARDIOLOGY, 2004, 27 (05) :295-299
[9]   Matlnspector and beyond: promoter analysis based on transcription factor binding sites [J].
Cartharius, K ;
Frech, K ;
Grote, K ;
Klocke, B ;
Haltmeier, M ;
Klingenhoff, A ;
Frisch, M ;
Bayerlein, M ;
Werner, T .
BIOINFORMATICS, 2005, 21 (13) :2933-2942
[10]   Coenzyme Q10 combined with mild hypothermia after cardiac arrest - A preliminary study [J].
Damian, MS ;
Ellenberg, D ;
Gildemeister, R ;
Lauermann, J ;
Simonis, G ;
Sauter, W ;
Georgi, C .
CIRCULATION, 2004, 110 (19) :3011-3016