The immune system and the gut microbiota: friends or foes?

被引：504

作者：

Cerf-Bensussan, Nadine ^{[1
,2
]}

Gaboriau-Routhiau, Valerie ^{[1
,2
]}

机构：

[1] Univ Paris 05, INSERM, U989, F-75730 Paris 15, France

[2] INRA, UM1319, F-78350 Jouy En Josas, France

来源：

NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 10期

关键词：

SEGMENTED FILAMENTOUS BACTERIA; INFLAMMATORY-BOWEL-DISEASE; INTESTINAL EPITHELIAL-CELLS; INDUCED CYTIDINE DEAMINASE; ACTIVATED RECEPTOR-GAMMA; T-BET DEFICIENCY; DENDRITIC CELLS; MAINTAIN HOMEOSTASIS; ULCERATIVE-COLITIS; AUTOIMMUNE-DISEASE;

D O I：

10.1038/nri2850

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The mammalian intestine is home to a complex community of trillions of bacteria that are engaged in a dynamic interaction with the host immune system. Determining the principles that govern host-microbiota relationships is the focus of intense research. Here, we describe how the intestinal microbiota is able to influence the balance between pro-inflammatory and regulatory responses and shape the host's immune system. We suggest that improving our understanding of the intestinal microbiota has therapeutic implications, not only for intestinal immunopathologies but also for systemic immune diseases.

引用

页码：735 / 744

页数：10

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