Composition and function of PDZ protein complexes during cell polarization

被引:116
作者
Roh, MH
Margolis, B
机构
[1] Univ Michigan, Med Ctr, Howard Hughes Med Inst, Sch Med, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Med, Dept Biol Chem, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109 USA
关键词
PSD-95/DiscsLarge/zonula occludens-1 domain; polarity; epithelia; cell junctions;
D O I
10.1152/ajprenal.00086.2003
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Complexes consisting of PDZ proteins have been implicated in a variety of cellular processes. In recent years, it has become increasingly clear that PDZ proteins play essential roles during the establishment of spatial asymmetry in various metazoan cell types such as epithelial cells. Epithelial cells possess asymmetry with respect to the apicobasal axis reflected by the differential distribution of proteins and lipids in the apical and basolateral surfaces. In Drosophila, three PDZ protein complexes have been shown to play crucial functions during the establishment of cell-cell adhesions and epithelial cell polarity: Bazooka/Dm-Par6/DaPKC, Crumbs/Stardust/Discs Lost, and Scribble/Discs Large/Lethal Giant Larvae. In this review, we focus primarily on our current knowledge of the localization and function of these complexes in Drosophila epithelia. We also discuss recent data that enhance our understanding of the homologous protein complexes and their roles during junctional assembly and polarization of mammalian epithelial cells.
引用
收藏
页码:F377 / F387
页数:11
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