Formation of self-assembled, air-stable lipid bilayer membranes on solid supports

被引：78

作者：

Ross, EE ^{[1
]}

Bondurant, B ^{[1
]}

Spratt, T ^{[1
]}

Conboy, JC ^{[1
]}

O'Brien, DF ^{[1
]}

Saavedra, SS ^{[1
]}

机构：

[1] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA

来源：

LANGMUIR | 2001年 / 17卷 / 08期

关键词：

D O I：

10.1021/la0101752

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A successful strategy for the self-assembly and stabilization of a substrate-supported, phospholipid bilayer is described. The bilayer is self-organized by fusion of fluid vesicles, composed of bis-sorbylphosphatidylcholine, on an oxide surface. The supported bilayer is then polymerized in situ to produce a cross-linked structure that is stable to surfactant solutions, organic solvents, and to transfer across the air/water interface, yet retains the resistance to nonspecific protein adsorption characteristic of a fluid phosphatidylcholine bilayer.

引用

页码：2305 / 2307

页数：3

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