NMR and polymorphism of a steroidal anaesthetic

被引：8

作者：

Harris, RK

Kenwright, AM

Fletton, RA

Lancaster, RW

机构：

[1] Univ Durham, Dept Chem, Durham DH1 3LE, England

[2] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 1998年 / 54卷 / 12期

关键词：

H-1 and C-13 NMR; polymorphism; steroidal anaesthetic; magic-angle spinning;

D O I：

10.1016/S1386-1425(98)00145-0

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Two modifications of 11 alpha-dimethylamino-2 beta-ethoxy-3 alpha-hydroxy-5 alpha-pregnan-20-one have been characterised by DSC, IR and Raman spectroscopies and by solid-state C-13 and N-15 NMR. Differences have been related to variations of hydrogen bonding as revealed by published single-crystal X-ray results. Solution-state H-1 and C-13 NMR results are also presented. The dimethylamino methyl groups are not exchanging on the NMR timescale, but their C-13 chemical shifts vary substantially between the solution and solid phases, suggesting a change of conformation. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

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页码：1837 / 1847

页数：11

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