High prevalence of metallo-β-lactamase and 16S rRNA methylase coproduction among imipenem-resistant Pseudomonas aeruginosa isolates in Brazil

被引:43
作者
Doi, Yohei
Ghilardi, Angela C. R.
Adams, Jennifer
Garcia, Doroti de Oliveira
Paterson, David L.
机构
[1] Univ Pittsburgh, Med Ctr, Div Infect Dis, Pittsburgh, PA 15213 USA
[2] Adolfo Lutz Inst, Sao Paulo, Brazil
关键词
D O I
10.1128/AAC.00443-07
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Rates of metallo-beta-lactamase and 16S rRNA methylase production were investigated in 51 imipenem-resistant Pseudomonas aeruginosa clinical isolates collected from hospitals in S (a) over baro Paulo, Brazil. Of them, 57% and 75% produced SPM-1 and RmtD, respectively. Of note, 51% produced both enzymes, suggesting that their coproduction is already common in this geographic area.
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页码:3388 / 3390
页数:3
相关论文
共 15 条
[1]  
Arakawa Y, 2000, J CLIN MICROBIOL, V38, P40
[2]  
Clinical and Laboratory Standards Institute, 2006, METH DIL ANT SUSC TE
[3]   Spread of novel aminoglycoside resistance gene aac(6′)-Iad among Acinetobacter clinical isolates in Japan [J].
Doi, Y ;
Wachino, J ;
Yamane, K ;
Shibata, N ;
Yagi, T ;
Shibayama, K ;
Kato, H ;
Arakawa, Y .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (06) :2075-2080
[4]   16S ribosomal RNA methylation: Emerging resistance mechanism against aminoglycosides [J].
Doi, Yohei ;
Arakawa, Yoshichika .
CLINICAL INFECTIOUS DISEASES, 2007, 45 (01) :88-94
[5]   Coproduction of novel 16S rRNA methylase RmtD and metallo-β-lactamase SPM-1 in a panresistant Pseudomonas aeruginosa isolate from Brazil [J].
Doi, Yohei ;
de Oliveira Garcia, Doroti ;
Adams, Jennifer ;
Paterson, David L. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (03) :852-856
[6]   Dissemination in distinct Brazilian regions of an epidemic carbapenem-resistant Pseudomonas aeruginosa producing SPM metallo-β-lactamase [J].
Gales, AC ;
Menezes, LC ;
Silbert, S ;
Sader, HS .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 52 (04) :699-702
[7]  
Kiffer Carlos, 2005, Braz J Infect Dis, V9, P216
[8]   Dissemination of 16S rRNA methylase-mediated highly amikacin-resistant isolates of Klebsiella pneumoniae and Acinetobacter baumannii in Korea [J].
Lee, Hyukmin ;
Yong, Dongeun ;
Yum, Jong Hwa ;
Roh, Kyoung Ho ;
Lee, Kyungwon ;
Yamane, Kunikazu ;
Arakawa, Yoshichika ;
Chong, Yunsop .
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2006, 56 (03) :305-312
[9]   MexXY-OprM efflux pump is required for antagonism of aminoglycosides by divalent cations in Pseudomonas aeruginosa [J].
Mao, WM ;
Warren, MS ;
Lee, A ;
Mistry, A ;
Lomovskaya, O .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (07) :2001-2007
[10]   Emerging carbapenemases in Gram-negative aerobes [J].
Nordmann, P ;
Poirel, L .
CLINICAL MICROBIOLOGY AND INFECTION, 2002, 8 (06) :321-331