How to survive in the host:: the Yersinia lesson

被引:49
作者
Bleves, S
Cornelis, GR
机构
[1] Univ Catholique Louvain, Christian Duve Inst Cellular Pathol, Microbial Pathogenesis Unit, B-1200 Brussels, Belgium
[2] Univ Catholique Louvain, Fac Med, B-1200 Brussels, Belgium
关键词
Yersinia; type III secretion; virulence; Yop effectors;
D O I
10.1016/S1286-4579(00)01300-9
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The Yop virulon allows Yersinia spp. to resist the immune response of the host: by injecting harmful proteins into host cells. It is composed of four elements: (i) type III secretion machinery called Ysc; (ii) a set of proteins required to translocate the effector proteins inside the eukaryotic cells; (iii) a control system, and (iv) six Yop effector proteins. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码:1451 / 1460
页数:10
相关论文
共 81 条
[1]   YSCU, A YERSINIA-ENTEROCOLITICA INNER MEMBRANE-PROTEIN INVOLVED IN YOP SECRETION [J].
ALLAOUI, A ;
WOESTYN, S ;
SLUITERS, C ;
CORNELIS, GR .
JOURNAL OF BACTERIOLOGY, 1994, 176 (15) :4534-4542
[2]   MUTATIONAL ANALYSIS OF THE YERSINIA-ENTEROCOLITICA VIRC OPERON - CHARACTERIZATION OF YSCE, YSCF, YSCG, YSCI, YSCJ, YSCK REQUIRED FOR YOP SECRETION AND YSCH ENCODING YOPR [J].
ALLAOUI, A ;
SCHULTE, R ;
CORNELIS, GR .
MOLECULAR MICROBIOLOGY, 1995, 18 (02) :343-355
[3]   A mRNA signal for the type III secretion of Yop proteins by Yersinia enterocolitica [J].
Anderson, DM ;
Schneewind, O .
SCIENCE, 1997, 278 (5340) :1140-1143
[4]   YopH of Yersinia pseudotuberculosis interrupts early phosphotyrosine signalling associated with phagocytosis [J].
Andersson, K ;
Carballeira, N ;
Magnusson, KE ;
Persson, C ;
Stendahl, O ;
WolfWatz, H ;
Fallman, M .
MOLECULAR MICROBIOLOGY, 1996, 20 (05) :1057-1069
[5]   Identification of p130(Cas) as a substrate of Yersinia YopH (Yop51), a bacterial protein tyrosine phosphatase that translocates into mammalian cells and targets focal adhesions [J].
Black, DS ;
Bliska, JB .
EMBO JOURNAL, 1997, 16 (10) :2730-2744
[6]   The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranes [J].
Blocker, A ;
Gounon, P ;
Larquet, E ;
Niebuhr, K ;
Cabiaux, V ;
Parsot, C ;
Sansonetti, P .
JOURNAL OF CELL BIOLOGY, 1999, 147 (03) :683-693
[7]   Status of YopM and YopN in the Yersinia Yop virulon: YopM of Y-enterocolitica is internalized inside the cytosol of PU5-1.8 macrophages by the YopB, D, N delivery apparatus [J].
Boland, A ;
Sory, MP ;
Iriarte, M ;
Kerbourch, C ;
Wattiau, P ;
Cornelis, GR .
EMBO JOURNAL, 1996, 15 (19) :5191-5201
[8]   Role of YopP in suppression of tumor necrosis factor alpha release by macrophages during Yersinia infection [J].
Boland, A ;
Cornelis, GR .
INFECTION AND IMMUNITY, 1998, 66 (05) :1878-1884
[9]   Heparin interferes with translocation of Yop proteins into HeLa cells and binds to LcrG, a regulatory component of the Yersinia Yop apparatus [J].
Boyd, AP ;
Sory, MP ;
Iriarte, M ;
Cornelis, GR .
MOLECULAR MICROBIOLOGY, 1998, 27 (02) :425-436
[10]  
BOYD AP, 2000, IN PRESS J BACTERIOL, V181