Complanadine B, obscurumines A and B, new alkaloids from two species of Lycopodium

被引：52

作者：

Morita, H

Ishiuchi, K

Haganuma, A

Hoshino, T

Obara, Y

Nakahata, N

Kobayashi, J ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

[2] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan

来源：

TETRAHEDRON | 2005年 / 61卷 / 08期

关键词：

Lycopodium; alkaloid; dimer; neurotrophic factors; astrocytoma cells;

D O I：

10.1016/j.tet.2005.01.011

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new dirtier of C16N2 type alkaloid, complanadine B (1), and two new C16N type alkaloids, obscurumines A (2) and B (3), have been isolated from the club moss Lycopodium complanatum and L obscurum, respectively. The structures and stereochemistry of 1-3 were elucidated by combination of 2D NMR spectra and chemical transformation. Complanadine A (4) isolated together with 1 induced secretion of neurotrophic factors from human astrocytoma cells. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1955 / 1960

页数：6

共 39 条

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