Reduction of cerebral infarction in stroke-prone spontaneously hypertensive rats by statins associated with amelioration of oxidative stress

被引：58

作者：

Nagotani, S ^{[1
]}

Hayashi, T ^{[1
]}

Sato, K ^{[1
]}

Zhang, WR ^{[1
]}

Deguchi, K ^{[1
]}

Nagano, I ^{[1
]}

Shoji, M ^{[1
]}

Abe, K ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Med & Dent, Dept Neurol, Okayama 7008558, Japan

来源：

STROKE | 2005年 / 36卷 / 03期

关键词：

cerebral infarction; HMG-CoA reductase inhibitors; oxidative stress; rats; inbred SHR;

D O I：

10.1161/01.STR.0000155732.27333.3c

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-This study aimed to clarify the effect of statins on spontaneous stroke and to examine the antioxidative effect in artificial transient middle cerebral artery occlusion (tMCAO). Methods-Stroke-prone spontaneous hypertensive rats (SHR-SP) were treated with pitavastatin, atorvastatin, simvastatin, or vehicle for 4 weeks. Physiological parameters, serum lipids, and infarct volumes were examined. The markers for oxidative stresses on lipids and DNA were immunohistochemically detected in vehicle-treated or simvastatin-treated SHR-SP with tMCAO. Results-Atorvastatin and simvastatin decreased infarct volumes, with simvastatin most effective. Simvastatin significantly reduced immunoreactivities for oxidative stress markers for lipids and DNA in neurons after tMCAO. Conclusions-The results suggest that the antioxidative properties of statins may be implicated in their beneficial effects against neuronal damage in cerebral ischemia.

引用

页码：670 / 672

页数：3

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