Association between Alzheimer's disease and a functional polymorphism in the myeloperoxidase gene

被引：58

作者：

Crawford, FC

Freeman, MJ

Schinka, JA

Morris, MD

Abdullah, LI

Richards, D

Sevush, S

Duara, R

Mullan, MJ

机构：

[1] Roskamp Inst, Tampa, FL 33613 USA

[2] Univ S Florida, Memory Disorder Clin, Tampa, FL 33613 USA

[3] Univ Miami, Memory Disorder Clin, Miami, FL 33136 USA

[4] Mt Sinai Memory Disorder Clin, Miami Beach, FL 33140 USA

来源：

EXPERIMENTAL NEUROLOGY | 2001年 / 167卷 / 02期

关键词：

D O I：

10.1006/exnr.2000.7560

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A polymorphism in the Myeloperoxidase gene (MPO) has previously been demonstrated to be associated with gender-specific risk in an Alzheimers Disease (AD) autopsy sample. We have investigated this polymorphism in our own samples of 226 Caucasian cases and 166 controls and 59 Hispanic cases and 75 controls. In Caucasians we find a significant association between MPO genotype and AD (P = 0.03), although we do not observe any effects of gender or any interaction with the APOE gene. Specifically, the MPO GG; genotype contributes a 1.57-fold increased risk for AD. In Hispanics there was no effect of MPO genotype, or of MPO genotype in interaction with age or gender, on diagnosis of AD. (C) 2001 Academic Press.

引用

页码：456 / 459

页数：4

共 16 条

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