Geminin bans replication licence

被引：23

作者：

Madine, M ^{[1
]}

Laskey, R

机构：

[1] Imperial Canc Res Fund, Clare Hall Labs, Chromosomal Replicat Lab, S Minns, Herts, England

[2] Univ Cambridge, Wellcome CRC Inst, Cambridge CB2 1QR, England

来源：

NATURE CELL BIOLOGY | 2001年 / 3卷 / 02期

关键词：

D O I：

10.1038/35055158

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent work has clarified how higher eukaryotic cells 'licence' DNA replication precisely once per cycle. An inhibitor, geminin, prevents replication before mitosis by inhibiting the replication factor Cdt1, Degradation of geminin in anaphase allows Cdt1 to promote binding of MCM proteins, and hence DNA replication.

引用

页码：E49 / E50

页数：2

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