11β-hydroxysteroid dehydrogenase (11β-HSD-II) activity in human placenta:: Its relationship to placental weight and birth weight and its possible role in hypertension

It has been assumed that low birth weight and high placenta weight were key factors for predicting hypertension in human adulthood. A deficiency in placental 11 beta -HSD-II enzyme activity was supposed to be the underlying cause. To possibly establish 11 beta -HSD-II as a leading factor, we determined 11 beta -HSD-II activities in 133 healthy pregnancies, 21 proteinuric pregnancies complicated by pregnancy-induced hypertension (PIH), 26 non proteinuric PIH pregnancies and 15 pregnancies complicated by fatal growth restriction (32nd-41st gestational week). We could not identify differences in 11 beta -HSD-II activity between pregnancies with the rare combination of small babies with big placentas and others (p = 0.59; Kruskal-Wallis test). And although there was no correlation between 11 beta -HSD-II activity and birth weight, in the control gestational age correlated with 11 beta -HSD-II activity (r = 0.22; p < 0.05; Spearman). 11<beta>-HSD-II activity in the proteinuric PIH group was significantly higher than in the controls (11,7 pmol/min/mg prot.; range 10-13,2 vs. 7,9; range 7,0-91; p < 0,05). The lowest, but not significant, enzyme activities were in the IUGR group (5,8 pmol/min/mg prot.: range 4,0 - 9,2). In this group, analysis of variance detected a correlation between enzyme activity and placental weight. In conclusion, we could not confirm that placental 11<beta>-HSD-II deficiencies act as an indicator for the risk of adult hypertension in small fetuses with large placentas. However, in growth restriction 11 beta -HSD-II activity might play a role. To clarify the influence in this group, further research is needed. Increased 11 beta -HSD-II activities with gestational age in the control may serve to sustain fatal adrenal steroid genesis and to prepare the fetus for autonomic lift.