Signaling via toll-like receptor 5 can initiate inflammatory mediator production by murine osteoblasts

被引：34

作者：

Madrazo, DR ^{[1
]}

Tranguch, SL ^{[1
]}

Marriott, I ^{[1
]}

机构：

[1] Univ N Carolina, Dept Biol, Charlotte, NC 28223 USA

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 09期

关键词：

D O I：

10.1128/IAI.71.9.5418-5421.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Murine osteoblasts express Toll-like receptor 5 (TLR5), and this expression is upregulated following exposure to bacteria or to the TLR5 agonist, flagellin. Importantly, flagellin activates transcriptional regulators and elicits proinflammatory cytokine production, suggesting TLR5 functionality. TLR5 may represent an important mechanism underlying the recognition of bacterial pathogens by osteoblasts during bone infections.

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页码：5418 / 5421

页数：4

相关论文

共 25 条

[1] Streptococcus aureus infection of mouse or human osteoblasts induces high levels of interleukin-6 and interleukin-12 production [J].

Bost, KL ;

Ramp, WK ;

Nicholson, NC ;

Bento, JL ;

Marriott, I ;

Hudson, MC .

JOURNAL OF INFECTIOUS DISEASES, 1999, 180 (06) :1912-1920

[2] Induction of colony-stimulating factor expression following Staphylococcus or Salmonella interaction with mouse or human osteoblasts [J].

Bost, KL ;

Bento, JL ;

Ellington, JK ;

Marriott, I ;

Hudson, MC .

INFECTION AND IMMUNITY, 2000, 68 (09) :5075-5083

[3] Monocyte chemoattractant protein-1 expression by osteoblasts following infection with Staphylococcus aureus or Salmonella [J].

Bost, KL ;

Bento, JL ;

Petty, CC ;

Schrum, LW ;

Hudson, MC ;

Marriott, I .

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2001, 21 (05) :297-304

[4] Cultured astrocytes express toll-like receptors for bacterial products [J].

Bowman, CC ;

Rasley, A ;

Tranguch, SL ;

Marriott, I .

GLIA, 2003, 43 (03) :281-291

[5] Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction [J].

Chow, JC ;

Young, DW ;

Golenbock, DT ;

Christ, WJ ;

Gusovsky, F .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (16) :10689-10692

[6] Bacterium-induced CXCL10 secretion by osteoblasts can be mediated in part through toll-like receptor 4 [J].

Gasper, NA ;

Petty, CC ;

Schrum, LW ;

Marriott, I ;

Bost, KL .

INFECTION AND IMMUNITY, 2002, 70 (08) :4075-4082

[7] Cutting edge: Bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression [J].

Gewirtz, AT ;

Navas, TA ;

Lyons, S ;

Godowski, PJ ;

Madara, JL .

JOURNAL OF IMMUNOLOGY, 2001, 167 (04) :1882-1885

[8] The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5 [J].

Hayashi, F ;

Smith, KD ;

Ozinsky, A ;

Hawn, TR ;

Yi, EC ;

Goodlett, DR ;

Eng, JK ;

Akira, S ;

Underhill, DM ;

Aderem, A .

NATURE, 2001, 410 (6832) :1099-1103

[9] A Toll-like receptor recognizes bacterial DNA [J].

Hemmi, H ;

Takeuchi, O ;

Kawai, T ;

Kaisho, T ;

Sato, S ;

Sanjo, H ;

Matsumoto, M ;

Hoshino, K ;

Wagner, H ;

Takeda, K ;

Akira, S .

NATURE, 2000, 408 (6813) :740-745

[10]

Hoshino K, 1999, J IMMUNOL, V162, P3749