Regulatory function of CD4+CD25++ T cells in patients with myasthenia gravis is associated with phenotypic changes and STAT5 signaling: 1,25-Dihydroxyvitamin D3 modulates the suppressor activity

被引：33

作者：

Alahgholi-Hajibehzad, Mandi ^{[1
,2
]}

Oflazer, Piraye ^{[3
]}

Aysal, Fikret ^{[4
]}

Durmus, Hacer ^{[3
]}

Gulsen-Parman, Yesim ^{[3
]}

Marx, Alexander ^{[5
]}

Deymeer, Feza ^{[3
]}

Saruhan-Direskeneli, Guher ^{[1
]}

机构：

[1] Istanbul Univ, Dept Physiol, Istanbul Med Fac, Istanbul, Turkey

[2] Istanbul Univ, Dept Immunol, Inst Expt Med DETAE, Istanbul, Turkey

[3] Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey

[4] Bakirkoy Res & Training Hosp Psychiat & Neurol Di, Dept Neurol, Istanbul, Turkey

[5] Heidelberg Univ, Univ Med Ctr Mannheim, Inst Pathol, Mannheim, Germany

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2015年 / 281卷

关键词：

Treg; GITR; PD-1; STAT-5; Vitamin D; LOMG; VITAMIN-D DEFICIENCY; DENDRITIC CELLS; B-CELLS; EXPRESSION; CYTOKINES; FOXP3; IL-2; TOLERANCE; MECHANISM; D-3;

D O I：

10.1016/j.jneuroim.2015.03.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory T cells were investigated in early-onset (EO) and late-onset (LO) myasthenia gravis patients with anti-acetylcholine receptor antibody (AChR-MG). Alterations in PD-1 and PD-L1 on CD4(+)CD25(++) (Treg) and responder T cells (Tresp, CD4(+)CD25(-)) were observed in LOMG patients. GITR was decreased on CD4(+)CD25(++) of all patients. Decrease of FOXP3 was associated with lower phosphorylation of STAT5.1,25-dihydroxyvitamin D3 (VitD3) increased suppression in co-culture with a stronger effect in patients by acting possibly both on cell groups. Changes in surface molecules and intracellular pathways contribute to the defects of Treg in non-thymomatous AChR-MG and VitD3 can have modulatory effects. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：51 / 60

页数：10

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