Atrial Substrate Properties and Outcome of Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation Associated With Diabetes Mellitus or Impaired Fasting Glucose

被引：113

作者：

Chao, Tze-Fan ^{[1
,2
,3
]}

Suenari, Kazuyoshi ^{[1
,4
]}

Chang, Shih-Lin ^{[1
,2
,3
]}

Lin, Yenn-Jiang ^{[1
,2
,3
]}

Lo, Li-Wei ^{[1
,2
,3
]}

Hu, Yu-Feng ^{[1
,2
,3
]}

Tuan, Ta-Chuan ^{[1
,2
,3
]}

Tai, Ching-Tai ^{[1
,2
,3
]}

Tsao, Hsuan-Ming ^{[5
]}

Li, Cheng-Hung ^{[1
,2
,3
]}

Ueng, Kuo-Chang ^{[6
]}

Wu, Tsu-Juey ^{[7
]}

Chen, Shih-Ann ^{[1
,2
,3
]}

机构：

[1] Taipei Vet Gen Hosp, Div Cardiol, Dept Med, Taipei, Taiwan

[2] Natl Yang Ming Univ, Inst Clin Med, Taipei 112, Taiwan

[3] Natl Yang Ming Univ, Cardiovasc Res Ctr, Taipei 112, Taiwan

[4] Hiroshima Univ, Dept Cardiovasc Med, Grad Sch Biomed Sci, Hiroshima, Japan

[5] Natl Yang Ming Univ Hosp, Div Cardiol, Ilan, Taiwan

[6] Chung Shan Med Univ, Div Cardiol & Cardiovasc Surg, Inst Med, Taichung, Taiwan

[7] Taichung Vet Gen Hosp, Div Cardiol, Dept Med, Taichung, Taiwan

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2010年 / 106卷 / 11期

关键词：

INDEPENDENT RISK; NATURAL-HISTORY; PREDICTORS; RECURRENCE; PROGNOSIS; MORTALITY; OBESITY; IMPACT;

D O I：

10.1016/j.amjcard.2010.07.038

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetes mellitus has been reported to be an independent risk factor of atrial fibrillation (AF). The present study investigated the atrial substrate properties and clinical outcome of catheter ablation in patients with paroxysmal AF and abnormal glucose metabolism. A total of 228 patients with paroxysmal AF who had undergone catheter ablation for the first time were enrolled. An abnormal glucose metabolism (n = 65) was defined as diabetes mellitus or an impaired fasting glucose. We analyzed the clinical and electrophysiologic characteristics in, and the clinical outcome of, patients with AF with and without an abnormal glucose metabolism. The right atrial (107.2 +/- 15.4 vs 96.0 +/- 16.5 ms, p <0.001) and left atrial (108.4 +/- 22.3 vs 94.0 +/- 17.5 ms, p <0.001) total activation times were significantly longer in the patients with AF and an abnormal glucose metabolism than in those without an abnormal metabolism. Furthermore, the right atrial (1.46 +/- 0.61 vs 2.00 +/- 0.70 mV, p <0.001) and left atrial (1.48 +/- 0.74 vs 2.05 +/- 0.78 mV, p <0.001) bipolar voltages were significantly lower in those with AF and an abnormal glucose metabolism than in those without. The AF recurrence rate was also greater in the patients with an abnormal glucose metabolism (18.5% vs 8.0%, p = 0.022) than in those without. The follow-up duration was 18.8 +/- 6.4 months. In conclusion, an abnormal glucose metabolism affects the biatrial substrate properties with an intra-atrial conduction delay, decreased voltage, and greater recurrence rate after catheter ablation. (C) 2010 Elsevier Inc. All rights reserved. (Am J Cardiol 2010;106:1615-1620)

引用

页码：1615 / 1620

页数：6

共 27 条

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