ALT-711 decreases cardiovascular stiffness and has potential in diabetes, hypertension and heart failure

被引：7

作者：

Doggrell, SA ^{[1
]}

机构：

[1] Doggrell Biomed Commun, Auckland, New Zealand

来源：

EXPERT OPINION ON INVESTIGATIONAL DRUGS | 2001年 / 10卷 / 05期

关键词：

ALT-711; cardiac stiffness; vascular stiffness;

D O I：

10.1517/13543784.10.5.981

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Vascular and/or myocardial stiffness is a major problem in ageing, diabetes, hypertension and heart failure. The development of the stiffness is partly due to the formation of glucose-dependent cross-links in the collagen. ALT-711 cleaves these cross-links. In aged-rhesus monkeys, ALT-711 decreases vascular stiffness and this effect is reversible. ALT-711 also decreases myocardial stiffness in the monkeys bur this effect is not reversible in 39 weeks. ALT-711 has potential in the treatment of the stiffness associated with diabetes, hypertension and heart failure.

引用

页码：981 / 983

页数：3

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