Pulmonary and cardiovascular effects of acute exposure to concentrated ambient particulate matter in rats

被引：68

作者：

Gordon, T ^{[1
]}

Nadziejko, C ^{[1
]}

Schlesinger, R ^{[1
]}

Chen, LC ^{[1
]}

机构：

[1] NYU, Sch Med, Dept Environm Med, Tuxedo Park, NY 10987 USA

来源：

TOXICOLOGY LETTERS | 1998年 / 96-7卷

关键词：

particulate matter; monocrotaline; respiratory effects; rat;

D O I：

10.1016/S0378-4274(98)00084-8

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

To examine the biological plausibility of the adverse health effects of ambient particulate matter (PM), we have studied the cardio-pulmonary effects of PM in an animal model of pulmonary hypertension. Normal and monocrotaline-treated rats were exposed, nose-only, for 3 h to filtered air or concentrated ambient PM. At 3 h-but not 24 h-post-exposure, the percentage of neutrophils in peripheral blood was significantly elevated in PM-exposed animals while the percentage of lymphocytes was decreased with no change in white blood cell counts. These changes in white blood cell differential occurred in both normal and monocrotaline-treated animals. Small, but consistent changes in heart rate, but not core temperature, were observed after exposure to concentrated ambient PM. Pulmonary injury, as evidenced by increased protein levels in lavage fluid, occurred only in monocrotaline-treated animals exposed to >360 mu g/m(3) PM. The observed pattern of hematological and cardiac changes suggests an activation of the sympathetic stress response. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：285 / 288

页数：4