Apoptosis: caspases orchestrate the ROCK 'n' bleb

被引：63

作者：

Leverrier, Y

Ridley, AJ

机构：

[1] Ludwig Inst Canc Res, London W1W 7BS, England

[2] UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England

来源：

NATURE CELL BIOLOGY | 2001年 / 3卷 / 04期

关键词：

D O I：

10.1038/35070151

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although membrane blebbing is a characteristic morphological change associated with apoptosis, little is known about the mechanisms underlying this process. New research has identified the Rho GTPase targe ROCK-I as being cleaved by caspases during apoptosis. ROCK-I is known to stimulate actomyosin-based contractility. Once cleaved, ROCK-I Is constitutively active and is responsible for bleb formation In apoptotic cells.

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页码：E91 / E93

页数：3

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