4-Phenylcoumarins from Mesua elegans with acetylcholinesterase inhibitory activity

被引：52

作者：

Awang, Khalijah ^{[1
]}

Chan, Gomathi ^{[1
]}

Litaudon, Marc ^{[2
]}

Ismail, Nor Hadiani ^{[3
]}

Martin, Marie-Therese ^{[2
]}

Gueritte, Francoise ^{[2
]}

机构：

[1] Univ Malaya, Fac Sci, Kuala Lumpur 50603, Malaysia

[2] CNRS, Ctr Rech Gif, Inst Chim Subst Nat, UPR2301, Gif Sur Yvette, France

[3] Univ Teknol MARA, Fac Sci Appl, Shah Alam 40450, Selangor, Malaysia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2010年 / 18卷 / 22期

关键词：

Mesua elegans; Clusiaceae; Acetylcholinesterase; 4-Phenylcoumarin; XANTHONES;

D O I：

10.1016/j.bmc.2010.09.044

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A significant acetylcholinesterase (AChE) inhibitory activity was observed for the hexane extract from the bark of Mesua elegans (Clusiaceae). Thus, the hexane extract was subjected to chemical investigation, which led to the isolation of nine 4-phenylcoumarins, in which three are new; mesuagenin A (1), mesuagenin C (3), mesuagenin D (4) and one new natural product; mesuagenin B (2). The structures of the isolated compounds were characterized by spectroscopic data interpretation, especially 1D and 2D NMR. Four compounds showed significant AChE inhibitory activity, with mesuagenin B (2) being the most potent (IC50 = 0.7 mu M). (C) 2010 Elsevier Ltd. All rights reserved.

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页码：7873 / 7877

页数：5

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