Peptidoglycan recognition in Drosophila

被引:44
作者
Aggrawal, K. [1 ]
Silverman, N. [1 ]
机构
[1] Univ Massachusetts, Sch Med, Dept Med, Div Infect Dis, Worcester, MA 01720 USA
关键词
antimicrobial peptide; Drosophilo; Gram-negative bacterium; Gram-positive bacterium; innate immune response; peptidoglycan; Toll pathway;
D O I
10.1042/BST0351496
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Drosophila rely primarily on innate immune responses to effectively combat a wide array of microbial pathogens. The hallmark of the Drosophila humoral immune response is the rapid production of AMPS (antimicrobial peptides) by the fat body, the insect homologue of the mammalian liver. Production of these AMPs is controlled at the level of transcription by two NF-kappa B (nuclear factor kappa B) signalling pathways. The Toll pathway is activated by fungal and many Gram-positive bacterial microbes, whereas the IMD (immune deficiency) pathway responds to Gram-negative bacteria and certain Gram-positive bacilli. in the present review, we discuss the mechanisms involved in bacterial recognition, in particular the differential recognition of various types of bacterial PGN (peptidoglycan) by different members of the PGRP (PGN recognition protein) family of receptors.
引用
收藏
页码:1496 / 1500
页数:5
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