Escape from X inactivation in mice and humans

被引：133

作者：

Berletch, Joel B. ^{[1
]}

Yang, Fan ^{[1
]}

Disteche, Christine M. ^{[1
,2
]}

机构：

[1] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[2] Univ Washington, Dept Med, Seattle, WA 98195 USA

来源：

GENOME BIOLOGY | 2010年 / 11卷 / 06期

基金：

美国国家卫生研究院;

关键词：

CHROMOSOME INACTIVATION; DOSAGE COMPENSATION; EPIGENETIC MARK; GENE-EXPRESSION; TURNER SYNDROME; XIST GENE; MOUSE; RNA; IDENTIFICATION; CHROMATIN;

D O I：

10.1186/gb-2010-11-6-213

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A subset of X-linked genes escapes silencing by X inactivation and is expressed from both X chromosomes in mammalian females. Species-specific differences in the identity of these genes have recently been discovered, suggesting a role in the evolution of sex differences. Chromatin analyses have aimed to discover how genes remain expressed within a repressive environment.

引用

页数：7

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